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    CMV drives the expansion of highly functional memory T cells expressing NK-cell receptors in renal transplant recipients

    255978.pdf (8.670Mb)
    Access Status
    Open access
    Authors
    Makwana, N.
    Foley, B.
    Fernandez, S.
    Lee, S.
    Irish, A.
    Pircher, H.
    Price, Patricia
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Makwana, N. and Foley, B. and Fernandez, S. and Lee, S. and Irish, A. and Pircher, H. and Price, P. 2017. CMV drives the expansion of highly functional memory T cells expressing NK-cell receptors in renal transplant recipients. European Journal of Immunology. 47 (8): pp. 1324-1334.
    Source Title
    European Journal of Immunology
    DOI
    10.1002/eji.201747018
    ISSN
    0014-2980
    School
    School of Biomedical Sciences
    Remarks

    This is the peer reviewed version of the following article: Makwana, N. and Foley, B. and Fernandez, S. and Lee, S. and Irish, A. and Pircher, H. and Price, P. 2017. CMV drives the expansion of highly functional memory T cells expressing NK-cell receptors in renal transplant recipients. European Journal of Immunology. 47 (8): pp. 1324-1334, which has been published in final form at 10.1002/eji.201747018. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-828039.html

    URI
    http://hdl.handle.net/20.500.11937/56920
    Collection
    • Curtin Research Publications
    Abstract

    Cytomegalovirus (CMV) is a common opportunistic infection encountered in renal transplant recipients (RTRs) and may be reactivated without symptoms at any time post-transplant. We describe how active and latent CMV affect T-cell subsets in RTRs who are stable on maintenance therapy. T-cell responses to CMV were assessed in RTRs (n = 54) > 2 years post-transplant, and healthy controls (n = 38). Seven RTRs had CMV DNA detectable in plasma. CMV antibody and DNA aligned with increased proportions of CD8 + T cells and reduced CD4/CD8 ratios. This paralleled an expansion of effector memory T-cell (T EM ), terminally differentiated T-cell (T EMRA ) and CD57 + T EMRA cell populations. Expression of NK-cell receptors, LIR-1 and KLRG1 on CD4 + and CD8 + CD57 + T EM and T EMRA cells correlated with elevated interferon-? and cytotoxic responses to anti-CD3 and increased cytotoxic responses to CMV phosphoprotein (pp) 65 in RTRs who carried CMV DNA. CD8 + T cells from all CMV seropositive RTRs responded efficiently to CMV immediate early (IE) -1 peptides. The data show that latent and active CMV infection can alter T-cell subsets in RTRs many years after transplantation, and up-regulate T-cell expression of NK-cell receptors. This may enhance effector responses of CD4 + and CD8 + T cells against CMV.

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