CMV drives the expansion of highly functional memory T cells expressing NK-cell receptors in renal transplant recipients
Embargo Lift Date
MetadataShow full item record
Cytomegalovirus (CMV) is a common opportunistic infection encountered in renal transplant recipients (RTRs) and may be reactivated without symptoms at any time post-transplant. We describe how active and latent CMV affect T-cell subsets in RTRs who are stable on maintenance therapy. T-cell responses to CMV were assessed in RTRs (n = 54) > 2 years post-transplant, and healthy controls (n = 38). Seven RTRs had CMV DNA detectable in plasma. CMV antibody and DNA aligned with increased proportions of CD8 + T cells and reduced CD4/CD8 ratios. This paralleled an expansion of effector memory T-cell (T EM ), terminally differentiated T-cell (T EMRA ) and CD57 + T EMRA cell populations. Expression of NK-cell receptors, LIR-1 and KLRG1 on CD4 + and CD8 + CD57 + T EM and T EMRA cells correlated with elevated interferon-? and cytotoxic responses to anti-CD3 and increased cytotoxic responses to CMV phosphoprotein (pp) 65 in RTRs who carried CMV DNA. CD8 + T cells from all CMV seropositive RTRs responded efficiently to CMV immediate early (IE) -1 peptides. The data show that latent and active CMV infection can alter T-cell subsets in RTRs many years after transplantation, and up-regulate T-cell expression of NK-cell receptors. This may enhance effector responses of CD4 + and CD8 + T cells against CMV.
This is the peer reviewed version of the following article: Makwana, N. and Foley, B. and Fernandez, S. and Lee, S. and Irish, A. and Pircher, H. and Price, P. 2017. CMV drives the expansion of highly functional memory T cells expressing NK-cell receptors in renal transplant recipients. European Journal of Immunology. 47 (8): pp. 1324-1334, which has been published in final form at 10.1002/eji.201747018. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-828039.html
Showing items related by title, author, creator and subject.
Cytomegalovirus infection alters phenotypes of different ?d T-cell subsets in renal transplant recipients with long-term stable graft functionLee, S.; Affandi, Jacquita; Irish, A.; Price, P. (2017)© 2017 Wiley Periodicals, Inc. Cytomegalovirus (CMV) infection alters the phenotypic profiles of T-cells and NK cells in healthy and immunocompromised individuals. Here, we examined the effects of CMV infection on the ...
CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or ? d T-cells, in HIV patients responding to ARTTanaskovic, S.; Fernandez, S.; Price, Patricia; Lee, S.; French, M. (2010)Some severely immunodeficient HIV patients experience poor recovery of CD4 T-cell counts on antiretroviral therapy (ART). Evaluation of the function of thymopoiesis in T-cell production in individual patients requires a ...
The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMVWaters, S.; Lee, S.; Affandi, Jacquita; Irish, A.; Price, Patricia (2017)© 2017. Renal transplant recipients (RTR) display high burdens of cytomegalovirus (CMV) and accelerated cardiovascular change. NK cells can control CMV and may contribute to vascular pathologies. Polymorphisms in genes ...