Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes
MetadataShow full item record
There is a growing need for the development of nanoparticles, with imaging and drug delivery capabilities, to maintain cellular uptake but avoid protein attachment and recognition. In this study we have demonstrated that nanoparticles consisting of a poly(glycidyl methacrylate) (PGMA) core and a mixed brush architecture of methoxypoly(ethylene glycol) and poly(ethylenimine) (mPEG–PEI) on the surface can meet this need. Surface functionalization with PEI alone results in cellular uptake, but rapid protein attachment whereas PEG alone can avoid protein attachment but to the detriment of cellular uptake. A mixed copolymer brush of both PEI and mPEG provides the ideal balance.
This work was funded by the Australian Research Council (ARC), the National Health & Medical Research Council (NHMRC) of Australia, and the Raine Medical Research Foundation
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see 10.1021/acsmacrolett.6b00613, see http://pubs.acs.org/page/policy/articlesonrequest/index.html.
Showing items related by title, author, creator and subject.
Pervaiz, Shazib (2018)© 2018, Mary Ann Liebert, Inc., publishers. Cellular redox state is a consequence of the balance between the rates of reactive oxygen species and/or reactive nitrogen species, and their dissipation via enzymatic and ...
Na+/H+ exchanger 1 (NHE-1) redox-regulated gene and intracellular target for the redox control of cell death sensitivityAkram, S.; Pervaiz, Shazib; Clement, M. (2011)Cell number in a multi-cellular organism is constant but dynamic. Cells are constantly undergoing growth; dead cells are replaced by new ones. Redox regulation of cell death has seen a paradigm shift in recent times. From ...
Immunological profiles of Bos taurus and Bos indicus cattle infested with the cattle tick, Rhipicephalus (Boophilus) microplusPiper, E.; Jonsson, N.; Gondro, C.; Lew-Tabor, A.; Moolhuijzen, Paula; Vance, M.; Jackson, L. (2009)The cattle tick, Rhipicephalus (Boophilus) microplus, is a major threat to the improvement of cattle production in tropical and subtropical countries worldwide. Bos indicus cattle are naturally more resistant to infestation ...