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dc.contributor.authorClemons, T.
dc.contributor.authorChallenor, M.
dc.contributor.authorFitzgerald, Melinda
dc.contributor.authorDunlop, S.
dc.contributor.authorSmith, N.
dc.contributor.authorSwaminathan Iyer, K.
dc.date.accessioned2017-09-27T10:21:53Z
dc.date.available2017-09-27T10:21:53Z
dc.date.created2017-09-27T09:48:16Z
dc.date.issued2016
dc.identifier.citationClemons, T. and Challenor, M. and Fitzgerald, M. and Dunlop, S. and Smith, N. and Swaminathan Iyer, K. 2016. Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes. ACS Macro Letters. 5 (10): pp. 1132-1136.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/56972
dc.identifier.doi10.1021/acsmacrolett.6b00613
dc.description.abstract

There is a growing need for the development of nanoparticles, with imaging and drug delivery capabilities, to maintain cellular uptake but avoid protein attachment and recognition. In this study we have demonstrated that nanoparticles consisting of a poly(glycidyl methacrylate) (PGMA) core and a mixed brush architecture of methoxypoly(ethylene glycol) and poly(ethylenimine) (mPEG–PEI) on the surface can meet this need. Surface functionalization with PEI alone results in cellular uptake, but rapid protein attachment whereas PEG alone can avoid protein attachment but to the detriment of cellular uptake. A mixed copolymer brush of both PEI and mPEG provides the ideal balance.

dc.titleManipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes
dc.typeJournal Article
dcterms.source.volume5
dcterms.source.startPage1132
dcterms.source.endPage1136
dcterms.source.titleACS Macro Letters
curtin.note

This work was funded by the Australian Research Council (ARC), the National Health & Medical Research Council (NHMRC) of Australia, and the Raine Medical Research Foundation

curtin.note

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see 10.1021/acsmacrolett.6b00613, see http://pubs.acs.org/page/policy/articlesonrequest/index.html.

curtin.departmentHealth Sciences Research and Graduate Studies
curtin.accessStatusOpen access


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