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Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy

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Open access
Authors
Dmello, D.
Ariyanto, I.
Estiasari, R.
Halstrom, S.
Gaff, Jessica
Lee, S.
Price, Patricia
Date
2017
Type
Journal Article

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Dmello, D. and Ariyanto, I. and Estiasari, R. and Halstrom, S. and Gaff, J. and Lee, S. and Price, P. 2017. Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy. Human Immunology. 78 (4): pp. 387-390.
Source Title
Human Immunology
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School of Biomedical Sciences
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Abstract

Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12 months on treatment. Heterozygosity at rs1518111 or rs1800872 associated with low CD4 T-cell counts at all time points. Both alleles were carried in two haplotypes. Haplotype 21122 (present in 30% of participants) associated with low CD4 T-cell counts, whereas 21222 (in 6% of participants) did not. Hence untyped SNP(s) tagged by 21122 may depress CD4 T-cell counts. The association with heterozygosity suggests synergy with an allele from a haplotype lacking rs1518111 and/or rs1800872.