Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy

Dmello, D. and Ariyanto, I. and Estiasari, R. and Halstrom, S. and Gaff, J. and Lee, S. and Price, P. 2017. Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy. Human Immunology. 78 (4): pp. 387-390.

Source Title

Human Immunology

DOI

10.1016/j.humimm.2017.03.001

ISSN

0198-8859

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/57230

Collection

Curtin Research Publications

Abstract

Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12 months on treatment. Heterozygosity at rs1518111 or rs1800872 associated with low CD4 T-cell counts at all time points. Both alleles were carried in two haplotypes. Haplotype 21122 (present in 30% of participants) associated with low CD4 T-cell counts, whereas 21222 (in 6% of participants) did not. Hence untyped SNP(s) tagged by 21122 may depress CD4 T-cell counts. The association with heterozygosity suggests synergy with an allele from a haplotype lacking rs1518111 and/or rs1800872.