Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells
|dc.identifier.citation||Mooranian, A. and Negrulj, R. and Takechi, R. and Jamieson, E. and Morahan, G. and Al-Salami, H. 2017. Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells. Therapeutic Delivery. 8 (10): pp. 833-842.|
© 2017 2017 Future Science Ltd. Aim: A semisynthetic primary bile acid (PBA) has exerted hypoglycemic effects in Type 1 diabetic animals, which were hypothesized to be due to its anti-inflammatory and cellular glucose-regulatory effects. Thus, the research purpose aimed to examine antidiabetic effects of a PBA, in terms of cellular inflammation and survival and insulin release, in the context of supporting ß-cell delivery and Type 1 diabetic treatment. Materials & methods: 10 formulations were prepared, five without PBA (control) and five with PBA (test). Formulations were used to microencapsulate pancreatic ß cells and the microcapsules were examined for morphology, cell viability, insulin release and inflammation. Results & conclusion: PBA improved cell viability, insulin release and reduced inflammation in a formulation-dependent manner, which suggests potential use in cell delivery and diabetes treatment.
|dc.title||Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells|
|curtin.department||School of Pharmacy|
|curtin.accessStatus||Fulltext not available|
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