Show simple item record

dc.contributor.authorMooranian, A.
dc.contributor.authorNegrulj, R.
dc.contributor.authorTakechi, R.
dc.contributor.authorJamieson, E.
dc.contributor.authorMorahan, G.
dc.contributor.authorAl-Salami, Hani
dc.identifier.citationMooranian, A. and Negrulj, R. and Takechi, R. and Jamieson, E. and Morahan, G. and Al-Salami, H. 2017. Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells. Therapeutic Delivery. 8 (10): pp. 833-842.

© 2017 2017 Future Science Ltd. Aim: A semisynthetic primary bile acid (PBA) has exerted hypoglycemic effects in Type 1 diabetic animals, which were hypothesized to be due to its anti-inflammatory and cellular glucose-regulatory effects. Thus, the research purpose aimed to examine antidiabetic effects of a PBA, in terms of cellular inflammation and survival and insulin release, in the context of supporting ß-cell delivery and Type 1 diabetic treatment. Materials & methods: 10 formulations were prepared, five without PBA (control) and five with PBA (test). Formulations were used to microencapsulate pancreatic ß cells and the microcapsules were examined for morphology, cell viability, insulin release and inflammation. Results & conclusion: PBA improved cell viability, insulin release and reduced inflammation in a formulation-dependent manner, which suggests potential use in cell delivery and diabetes treatment.

dc.titleAlginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells
dc.typeJournal Article
dcterms.source.titleTherapeutic Delivery
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record