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dc.contributor.authorMooranian, A.
dc.contributor.authorNegrulj, R.
dc.contributor.authorTakechi, R.
dc.contributor.authorJamieson, E.
dc.contributor.authorMorahan, G.
dc.contributor.authorAl-Salami, Hani
dc.date.accessioned2017-10-30T08:16:33Z
dc.date.available2017-10-30T08:16:33Z
dc.date.created2017-10-30T08:03:06Z
dc.date.issued2017
dc.identifier.citationMooranian, A. and Negrulj, R. and Takechi, R. and Jamieson, E. and Morahan, G. and Al-Salami, H. 2017. Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells. Therapeutic Delivery. 8 (10): pp. 833-842.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/57300
dc.identifier.doi10.4155/tde-2017-0042
dc.description.abstract

© 2017 2017 Future Science Ltd. Aim: A semisynthetic primary bile acid (PBA) has exerted hypoglycemic effects in Type 1 diabetic animals, which were hypothesized to be due to its anti-inflammatory and cellular glucose-regulatory effects. Thus, the research purpose aimed to examine antidiabetic effects of a PBA, in terms of cellular inflammation and survival and insulin release, in the context of supporting ß-cell delivery and Type 1 diabetic treatment. Materials & methods: 10 formulations were prepared, five without PBA (control) and five with PBA (test). Formulations were used to microencapsulate pancreatic ß cells and the microcapsules were examined for morphology, cell viability, insulin release and inflammation. Results & conclusion: PBA improved cell viability, insulin release and reduced inflammation in a formulation-dependent manner, which suggests potential use in cell delivery and diabetes treatment.

dc.titleAlginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells
dc.typeJournal Article
dcterms.source.volume8
dcterms.source.number10
dcterms.source.startPage833
dcterms.source.endPage842
dcterms.source.issn2041-5990
dcterms.source.titleTherapeutic Delivery
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available


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