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dc.contributor.authorDuke, J.
dc.contributor.authorRandall, Sean
dc.contributor.authorFear, M.
dc.contributor.authorO'Halloran, E.
dc.contributor.authorBoyd, James
dc.contributor.authorRea, S.
dc.contributor.authorWood, F.
dc.identifier.citationDuke, J. and Randall, S. and Fear, M. and O'Halloran, E. and Boyd, J. and Rea, S. and Wood, F. 2017. Long term cardiovascular impacts after burn and non-burn trauma: A comparative population-based study. Burns.

© 2017 Elsevier Ltd and ISBI. Objective: To compare post-injury cardiovascular disease (CVD) hospital admissions experienced by burn patients with non-burn trauma patients and people with no record of injury, adjusting for socio-demographic, health and injury factors. Methods: Linked hospital and death data were analysed for a cohort of burn patients (n = 30,997) hospitalised in Western Australia during the period 1980-2012 and age and gender frequency matched comparison cohorts (non-burn trauma: n = 28,647; non-injured: n = 123,399). The number and length of hospital stay for CVD admissions were used as outcome measures. Multivariate negative binomial regression was used to derive adjusted incidence rate ratios (IRR) and 95% confidence intervals (95%CI). Multivariate Cox regression models and hazard ratios (HR) were used to examine first time post-injury CVD admissions. Results: The burn cohort had a higher rate of CVD (combined) admissions (IRR, 95%CI: 1.16: 1.08-1.24) and spent longer in hospital (IRR, 95%CI: 1.37, 1.13-1.66) than the non-burn trauma cohort. Both the burn cohort (IRR, 95%CI: 1.50, 1.40-1.60) and the non-burn trauma cohort (IRR, 95%CI: 1.29, 1.21-1.37) had higher adjusted rates of post-injury CVD admissions compared with the non-injured cohort. The burn cohort (HR, 95%CI: 2.27, 1.70-3.02) and non-burn trauma cohort (HR, 95%CI: 2.19, 1.66-2.87) experienced significantly elevated first time CVD admissions during the first 6 months after injury, decreasing in magnitude from 6 months to 5 years after injury (HR, 95%CI: burn vs. non-injured; 1.31, 1.16-1.48; non-burn trauma vs. non-injured; 1.16, 1.03-1.31); no significant difference in incident admission rates was found beyond 5 years (HR, 95%CI: burn vs. non-injured; 0.99, 0.92-1.07; non-burn trauma vs. non-injured; 1.00, 0.93-1.07). Conclusions: Burn and non-burn trauma patients experience elevated rates of post-injury CVD admissions for a prolonged period after the initial injury and are particularly at increased risk of incident CVD admissions during the first 5-years after the injury event. Detailed clinical data are required to help understand the underlying pathogenic pathways triggered by burn and non-burn trauma. This study identified treatment needs for injury patients, burn and non-burn, for a prolonged period after discharge.

dc.publisherPergamon Press
dc.titleLong term cardiovascular impacts after burn and non-burn trauma: A comparative population-based study
dc.typeJournal Article
curtin.departmentCentre for Population Health Research
curtin.accessStatusFulltext not available

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