Robust multi-objective optimal switching control arising in 1,3-propanediol microbial fed-batch process
MetadataShow full item record
This paper considers optimal control of glycerol producing 1,3-propanediol (1,3-PD) via microbial fed-batch fermentation. The fed-batch process is formulated as a nonlinear switched time-delay system. In general, the time-delay in the fed-batch process cannot be exactly estimated. Our goal is to design an optimal switching control scheme to simultaneously maximize 1,3-PD productivity and 1,3-PD yield under time-delay uncertainty. Accordingly, we propose a robust multi-objective optimal switching control model, in which two objectives, i.e., 1,3-PD productivity and 1,3-PD yield, and their sensitivities with respect to uncertain time-delay are considered in the objective vector. The control variables in this problem are the feeding rate of glycerol, the switching instants and the terminal time of the process. By introducing an auxiliary dynamic system to calculate the objective sensitivities and performing a time-scaling transformation, we obtain an equivalent multi-objective optimal switching control problem in standard form. We then convert the equivalent multi-objective optimal control problem into a sequence of single-objective optimal switching control problems by using a modified normal boundary intersection method. A novel gradient-based single-objective solver combining control parameterization with constraint transcription technique is developed to solve these resulting single-objective optimal control problems. Finally, numerical results are provided to verify the effectiveness of the proposed solution approach.
Showing items related by title, author, creator and subject.
Liu, Chongyang; Gong, Zhaohua; Teo, Kok Lay; Feng, E. (2016)© 2016 Elsevier Inc.Maximization of productivity and minimization of consumption are two top priorities for biotechnological industry. In this paper, we model a fed-batch process as a nonlinear switched time-delay system. ...
Chai, Qinqin (2013)In this thesis, we develop new computational methods for three classes of dynamic optimization problems: (i) A parameter identification problem for a general nonlinear time-delay system; (ii) an optimal control problem ...
Liu, C.; Loxton, Ryan; Teo, Kok Lay (2014)In this paper, we consider a novel dynamic optimization problem for nonlinear multistage systems with time-delays. Such systems evolve over multiple stages, with the dynamics in each stage depending on both the current ...