Multi-objective optimization of nonlinear switched time-delay systems in fed-batch process
MetadataShow full item record
© 2016 Elsevier Inc.Maximization of productivity and minimization of consumption are two top priorities for biotechnological industry. In this paper, we model a fed-batch process as a nonlinear switched time-delay system. Taking the productivity of target product and the consumption rate of substrate as the objective functions, we present a multi-objective optimization problem involving the nonlinear switched time-delay system and subject to continuous state inequality constraints. To solve the multi-objective optimization problem, we first convert the problem into a sequence of single-objective optimization problems by using convex weighted sum and normal boundary intersection methods. A gradient-based single-objective solver incorporating constraint transcription technique is then developed to solve these single-objective optimization problems. Finally, a numerical example is provided to verify the effectiveness of the numerical solution approach. Numerical results show that the normal boundary intersection method in conjunction with the developed single-objective solver is more favourable than the convex weighted sum method.
Showing items related by title, author, creator and subject.
Robust multi-objective optimal switching control arising in 1,3-propanediol microbial fed-batch processLiu, Chongyang; Gong, Z.; Teo, Kok Lay; Sun, Jie; Caccetta, Louis (2017)© 2017 Elsevier Ltd This paper considers optimal control of glycerol producing 1,3-propanediol (1,3-PD) via microbial fed-batch fermentation. The fed-batch process is formulated as a nonlinear switched time-delay system. ...
Liu, C.; Gong, Z.; Teo, Kok Lay; Loxton, Ryan; Feng, E. (2016)In this paper, we propose a bi-objective dynamic optimization model involving a nonlinear time-delay system to optimize the 1,3-propanediol (1,3-PD) production in a microbial batch process, where the productivity of 1,3-PD ...
Ziari, I.; Ledwich, G.; Ghosh, Arindam; Platt, G. (2011)In this paper, a comprehensive planning methodology is proposed that can minimize the line loss, maximize the reliability and improve the voltage profile in a distribution network. The injected active and reactive power ...