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    Hospitalization in older patients due to adverse drug reactions - The need for a prediction tool

    Access Status
    Open access via publisher
    Authors
    Nair, N.
    Stafford, Leanne
    Peterson, G.
    Bereznicki, B.
    Castelino, R.
    Bereznicki, L.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Nair, N. and Stafford, L. and Peterson, G. and Bereznicki, B. and Castelino, R. and Bereznicki, L. 2016. Hospitalization in older patients due to adverse drug reactions - The need for a prediction tool. Clinical Interventions in Aging. 11: pp. 497-505.
    Source Title
    Clinical Interventions in Aging
    DOI
    10.2147/CIA.S99097
    ISSN
    1176-9092
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/58300
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 Parameswaran Nair et al.Adverse drug reactions (ADRs) represent a major burden on society, resulting in significant morbidity, mortality, and health care costs. Older patients living in the community are particularly susceptible to ADRs, and are at an increased risk of ADR-related hospitalization. This review summarizes the available evidence on ADR-related hospital admission in older patients living in the community, with a particular focus on risk factors for ADRs leading to hospital admission and the need for a prediction tool for risk of ADR-related hospitalization in these individuals. The reported proportion of hospital admissions due to ADRs has ranged from 6% to 12% of all admissions in older patients. The main risk factors or predictors for ADR-related admissions were advanced age, polypharmacy, comorbidity, and potentially inappropriate medications. There is a clear need to design intervention strategies to prevent ADR-related hospitalization in older patients. To ensure the cost-effectiveness of such strategies, it would be necessary to target them to those older individuals who are at highest risk of ADR-related hospitalization. Currently, there are no validated tools to assess the risk of ADRs in primary care. There is a clear need to investigate the utility of tools to identify high-risk patients to target appropriate interventions toward prevention of ADR-related hospital admissions.

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