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    Adverse Drug Reaction-Related Hospitalizations in Elderly Australians: A Prospective Cross-Sectional Study in Two Tasmanian Hospitals

    Access Status
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    Authors
    Parameswaran Nair, N.
    Stafford, Leanne
    Bereznicki, B.
    Curtain, C.
    Peterson, G.
    Connolly, M.
    Bereznicki, L.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Parameswaran Nair, N. and Stafford, L. and Bereznicki, B. and Curtain, C. and Peterson, G. and Connolly, M. and Bereznicki, L. 2017. Adverse Drug Reaction-Related Hospitalizations in Elderly Australians: A Prospective Cross-Sectional Study in Two Tasmanian Hospitals. Drug Safety. 40 (7): pp. 597-606.
    Source Title
    Drug Safety
    DOI
    10.1007/s40264-017-0528-z
    ISSN
    0114-5916
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/58354
    Collection
    • Curtin Research Publications
    Abstract

    © 2017, Springer International Publishing Switzerland. Introduction: Adverse drug reactions (ADRs) have been commonly cited as a major cause of hospital admissions in older individuals. However, despite the apparent magnitude of this problem, there are limited prospective data on ADRs as a cause of hospitalization in elderly medical patients. Objectives: The objective of this study was to evaluate the proportion, clinical characteristics, causality, severity, preventability, and outcome of ADR-related admissions in older patients admitted to two Tasmanian hospitals. Methods: We conducted a prospective cross-sectional study at the Royal Hobart and Launceston General Hospitals in Tasm ania, Australia. A convenience sample of patients, aged 65 years and older, undergoing unplanned overnight medical admissions was screened. ADR-related admissions were determined through expert consensus from detailed review of medical records and patient interviews. The causality, preventability and severity of each ADR-related admission were assessed. Results: Of 1008 admissions, the proportion of potential ADR-related medical admissions was 18.9%. Most (88.5%) ADR-related admissions were considered preventable. Cardiovascular complaints (29.3%) represented the most common ADRs, followed by neuropsychiatric (20.0%) and renal and genitourinary disorders (15.2%). The most frequently implicated drug classes were diuretics (23.9%), agents acting on the renin angiotensin system (16.4%), ß-blocking agents (7.1%), antidepressants (6.9%), and antithrombotic agents (6.9%). Application of the Naranjo algorithm found 5.8% definite, 70.1% probable, and 24.1% possible ADRs. ADR severity was rated moderate and severe in 97.9% and 2.1% of admissions, respectively. For most (93.2%) ADR-related admissions the ADR resolved and the patient recovered. Conclusion: Hospitalization due to an ADR is a common occurrence in this older population. There is need for future studies to implement and evaluate interventions to reduce the risk of ADR-related admissions in elderly populations.

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