Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules

Gardner, J.; Mamotte, Cyril; Jackaman, Connie; Nelson, Delia

doi:10.1016/j.arr.2017.07.002

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Authors

Gardner, J.

Mamotte, Cyril

Jackaman, Connie

Nelson, Delia

Date

2017

Type

Journal Article

Metadata

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Citation

Gardner, J. and Mamotte, C. and Jackaman, C. and Nelson, D. 2017. Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules. Ageing Research Reviews. 38: pp. 40-51.

Source Title

Ageing Research Reviews

DOI

10.1016/j.arr.2017.07.002

ISSN

1568-1637

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/58583

Collection

Curtin Research Publications

Abstract

© 2017 Elsevier B.V. Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to impaired anti-tumour immune responses in elderly people with cancer. Changes in checkpoint inhibitory molecules/pathways during aging may be one mechanism that impairs the ability of elderly DCs to activate T cells. However, little is currently known regarding the combined effects of aging and cancer on DC and T cell inhibitory molecules/pathways. In this review, we discuss our current understanding of the influence of aging and cancer on key DC and T cell inhibitory molecules/pathways, the potential underlying cellular and molecular mechanisms contributing to their modulation, and the possibility of therapeutically targeting inhibitory molecules in elderly cancer patients.