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dc.contributor.authorGardner, J.
dc.contributor.authorMamotte, Cyril
dc.contributor.authorJackaman, Connie
dc.contributor.authorNelson, Delia
dc.identifier.citationGardner, J. and Mamotte, C. and Jackaman, C. and Nelson, D. 2017. Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules. Ageing Research Reviews. 38: pp. 40-51.

© 2017 Elsevier B.V. Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to impaired anti-tumour immune responses in elderly people with cancer. Changes in checkpoint inhibitory molecules/pathways during aging may be one mechanism that impairs the ability of elderly DCs to activate T cells. However, little is currently known regarding the combined effects of aging and cancer on DC and T cell inhibitory molecules/pathways. In this review, we discuss our current understanding of the influence of aging and cancer on key DC and T cell inhibitory molecules/pathways, the potential underlying cellular and molecular mechanisms contributing to their modulation, and the possibility of therapeutically targeting inhibitory molecules in elderly cancer patients.

dc.titleModulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules
dc.typeJournal Article
dcterms.source.titleAgeing Research Reviews
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available

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