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dc.contributor.authorMcCoy, M.
dc.contributor.authorHemmings, C.
dc.contributor.authorAnyaegbu, C.
dc.contributor.authorAustin, S.
dc.contributor.authorLee-Pullen, T.
dc.contributor.authorMiller, T.
dc.contributor.authorBulsara, M.
dc.contributor.authorZeps, Nikolajs
dc.contributor.authorNowak, A.
dc.contributor.authorLake, R.
dc.contributor.authorPlatell, C.
dc.date.accessioned2017-11-28T06:37:22Z
dc.date.available2017-11-28T06:37:22Z
dc.date.created2017-11-28T06:21:47Z
dc.date.issued2017
dc.identifier.citationMcCoy, M. and Hemmings, C. and Anyaegbu, C. and Austin, S. and Lee-Pullen, T. and Miller, T. and Bulsara, M. et al. 2017. Tumour-infiltrating regulatory T cell density before neoadjuvant chemoradiotherapy for rectal cancer does not predict treatment response. Oncotarget. 8 (12): pp. 19803-19813.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/58847
dc.identifier.doi10.18632/oncotarget.15048
dc.description.abstract

Neoadjuvant (preoperative) chemoradiotherapy (CRT) decreases the risk of rectal cancer recurrence and reduces tumour volume prior to surgery. However, response to CRT varies considerably between individuals and factors associated with response are poorly understood. Foxp3 + regulatory T cells (Tregs) inhibit antitumour immunity and may limit any response to chemotherapy and radiotherapy. We have previously reported that a low density of Tregs in the tumour stroma following neoadjuvant CRT for rectal cancer is associated with improved tumour regression. Here we have examined the association between Treg density in pre-treatment diagnostic biopsy specimens and treatment response, in this same patient cohort. We aimed to determine whether pre-treatment tumour-infiltrating Treg density predicts subsequent response to neoadjuvant CRT. Foxp3 + , CD8 + and CD3 + cell densities in biopsy samples from 106 patients were assessed by standard immunohistochemistry (IHC) and evaluated for their association with tumour regression grade and survival. We found no association between the density of any T cell subset pre-treatment and clinical outcome, indicating that tumour-infiltrating Treg density does not predict response to neoadjuvant CRT in rectal cancer. Taken together with the findings of the previous study, these data suggest that in the context of neoadjuvant CRT for rectal cancer, the impact of chemotherapy and/or radiotherapy on anti-tumour immunity may be more important than the state of the pre-existing local immune response.

dc.publisherImpact Journals LLC
dc.titleTumour-infiltrating regulatory T cell density before neoadjuvant chemoradiotherapy for rectal cancer does not predict treatment response
dc.typeJournal Article
dcterms.source.volume8
dcterms.source.number12
dcterms.source.startPage19803
dcterms.source.endPage19813
dcterms.source.issn1949-2553
dcterms.source.titleOncotarget
curtin.accessStatusOpen access via publisher


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