Multiple-breath washout outcomes are sensitive to inflammation and infection in children with cystic fibrosis
|dc.identifier.citation||Ramsey, K. and Foong, R. and Grdosic, J. and Harper, A. and Skoric, B. and Clem, C. and Davis, M. et al. 2017. Multiple-breath washout outcomes are sensitive to inflammation and infection in children with cystic fibrosis. Annals of the American Thoracic Society. 14 (9): pp. 1436-1442.|
© 2017 by the American Thoracic Society. Rationale: The lung clearance index is a measure of ventilation distribution derived from the multiple-breath washout technique. The lung clearance index is increased in the presence of lower respiratory tract inflammation and infection in infants with cystic fibrosis; however, the associations during the preschool years are unknown. Objectives: We assessed the ability of the lung clearance index to detect the presence and extent of lower respiratory tract inflammation and infection in preschool children with cystic fibrosis. Methods: Ventilation distribution outcomes were assessed at 82 visits with 58 children with cystic fibrosis and at 38 visits with 31 healthy children aged 3-6 years. Children with cystic fibrosis also underwent bronchoalveolar lavage fluid collection for detection of lower respiratory tract inflammation and infection. Associations between multiple-breath washout indices and the presence and extent of airway inflammation and infection were assessed using linear mixed effects models. Results: Lung clearance index was elevated in children with cystic fibrosis (mean [SD], 8.00 [1.45] ) compared with healthy control subjects (6.67 [0.56]). In cystic fibrosis, the lung clearance index was elevated in individuals with lower respiratory tract infections (difference compared with uninfected [95% confidence interval] , 0.62 [0.06, 1.18]) and correlated with the extent of airway inflammation. Conclusions: These data suggest that the lung clearance index may be a useful surveillance tool for monitoring the presence and extent of lower airway inflammation and infection in preschool children with cystic fibrosis.
|dc.title||Multiple-breath washout outcomes are sensitive to inflammation and infection in children with cystic fibrosis|
|dcterms.source.title||Annals of the American Thoracic Society|
|curtin.department||School of Physiotherapy and Exercise Science|
|curtin.accessStatus||Fulltext not available|
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