Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    HIV patients, healthy aging and transplant recipients can reveal the hidden footprints of CMV.

    257389.pdf (585.5Kb)
    Access Status
    Open access
    Authors
    Waters, Shelley
    Brook, Emily
    Lee, Silvia
    Estiasari, R.
    Ariyanto, I.
    Price, Patricia
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Waters, S. and Brook, E. and Lee, S. and Estiasari, R. and Ariyanto, I. and Price, P. 2018. HIV patients, healthy aging and transplant recipients can reveal the hidden footprints of CMV. Clinical Immunology. 187: pp. 107-112.
    Source Title
    Clinical Immunology
    DOI
    10.1016/j.clim.2017.11.001
    ISSN
    1521-7035
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/58901
    Collection
    • Curtin Research Publications
    Abstract

    Cytomegalovirus (CMV) is a β-herpesvirus. Latent infections are common in all populations. However age-associated increases in levels of CMV-reactive antibody are testament to repeated reactivations and periods of viral replication. CMV has been associated with several diseases of aging, including vasculopathy and neurocognitive impairment. These conditions occur at a younger age in persons with particularly high burdens of CMV - transplant recipients and people living with HIV. Here we define the “clinical footprints” as immunopathologies triggered by CMV that develop over many years. A high burden of CMV also drives accumulation of multifunctional terminally-differentiated αβ T-cells, a novel population of Vδ2 − γδ T-cells, and a population of CD56lo NK cells lacking a key regulatory molecule. An understanding of these “immunological footprints” of CMV may reveal how they collectively promote the “clinical footprints” of the virus. This is explored here in transplant recipients, HIV patients and healthy aging.

    Related items

    Showing items related by title, author, creator and subject.

    • Bottom trawl fishing footprints on the world's continental shelves
      Amoroso, R.; Pitcher, C.; Rijnsdorp, A.; McConnaughey, R.; Parma, A.; Suuronen, P.; Eigaard, O.; Bastardie, F.; Hintzen, N.; Althaus, F.; Baird, S.; Black, J.; Buhl-Mortensen, L.; Campbell, A.; Catarino, R.; Collie, J.; Cowan, J.; Durholtz, D.; Engstrom, N.; Fairweather, T.; Fock, H.; Ford, R.; Gálvez, P.; Gerritsen, H.; Góngora, M.; González, J.; Hiddink, J.; Hughes, K.; Intelmann, S.; Jenkins, C.; Jonsson, P.; Kainge, P.; Kangas, M.; Kathena, J.; Kavadas, S.; Leslie, R.; Lewise, S.; Lundy, M.; Makin, D.; Martin, J.; Mazor, T.; Gonzalez-Mirelis, G.; Newman, Stephen; Papadopoulou, N.; Posen, P.; Rochester, W.; Russok, T.; Salal, A.; Semmens, J.; Silvan, C.; Tsoloso, A.; Vanelslander, B.; Wakefield, Corey; Wood, B.; Hilborn, R.; Kaiser, M.; Jennings, S. (2018)
      © 2018 National Academy of Sciences. All rights reserved. Bottom trawlers land around 19 million tons of fish and invertebrates annually, almost one-quarter of wild marine landings. The extent of bottom trawling footprint ...
    • Carbon footprint and embodied energy assessment of a civil works program in a residential estate of Western Australia
      Biswas, Wahidul (2013)
      Purpose: With building construction and demolition waste accounting for 50 % of land fill space, the diversion of reusable materials is essential for Perth’s environment. The reuse and recovery of embodied energy-intensive ...
    • Bioslurry as a Fuel. 2. Life-Cycle Energy and Carbon Footprints of Bioslurry Fuels from Mallee Biomass in Western Australia
      Yu, Yun; Wu, Hongwei (2010)
      This paper reports a life-cycle assessment on energy and carbon footprints of bio-oil/char slurry (i.e., bioslurry) fuel from mallee in Western Australia (WA). The results demonstrate that bioslurry fuels have small energy ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.