Implications of the WNT Signalling Pathway for Adipose-derived Mesenchymal Stem Cells in a Breast Tumour Environment
Access Status
Open access
Authors
Visweswaran, Malini
Date
2017Supervisor
Prof. Arunasalam Dharmarajan
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Sciences
School
School of Biomedical Sciences
Collection
Abstract
This study describes the various roles adipose-derived mesenchymal stem cells (ADSCs) play in a breast tumour environment. The ADSC-derived secreted factors inhibit breast tumour cell growth aspects, whereas the tumour-derived secreted factors transform ADSCs into tumour-associated fibroblasts (TAFs). Additionally, it highlights the role of Wnt antagonist sFRP4 and its peptides to further influence the activity of ADSC-derived secreted factors, to downregulate the transformation of ADSCs into TAFs, and in upregulating the adipogenic differentiation of ADSCs.
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