Implications of the WNT Signalling Pathway for Adipose-derived Mesenchymal Stem Cells in a Breast Tumour Environment
| dc.contributor.author | Visweswaran, Malini | |
| dc.contributor.supervisor | Prof. Arunasalam Dharmarajan | en_US |
| dc.date.accessioned | 2017-11-30T07:16:49Z | |
| dc.date.available | 2017-11-30T07:16:49Z | |
| dc.date.issued | 2017 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/59066 | |
| dc.description.abstract |
This study describes the various roles adipose-derived mesenchymal stem cells (ADSCs) play in a breast tumour environment. The ADSC-derived secreted factors inhibit breast tumour cell growth aspects, whereas the tumour-derived secreted factors transform ADSCs into tumour-associated fibroblasts (TAFs). Additionally, it highlights the role of Wnt antagonist sFRP4 and its peptides to further influence the activity of ADSC-derived secreted factors, to downregulate the transformation of ADSCs into TAFs, and in upregulating the adipogenic differentiation of ADSCs. | en_US |
| dc.publisher | Curtin University | en_US |
| dc.title | Implications of the WNT Signalling Pathway for Adipose-derived Mesenchymal Stem Cells in a Breast Tumour Environment | en_US |
| dc.type | Thesis | en_US |
| dcterms.educationLevel | PhD | en_US |
| curtin.department | School of Biomedical Sciences | en_US |
| curtin.accessStatus | Open access | en_US |
| curtin.faculty | Health Sciences | en_US |