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dc.contributor.authorVisweswaran, Malini
dc.contributor.supervisorProf. Arunasalam Dharmarajanen_US
dc.date.accessioned2017-11-30T07:16:49Z
dc.date.available2017-11-30T07:16:49Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.11937/59066
dc.description.abstract

This study describes the various roles adipose-derived mesenchymal stem cells (ADSCs) play in a breast tumour environment. The ADSC-derived secreted factors inhibit breast tumour cell growth aspects, whereas the tumour-derived secreted factors transform ADSCs into tumour-associated fibroblasts (TAFs). Additionally, it highlights the role of Wnt antagonist sFRP4 and its peptides to further influence the activity of ADSC-derived secreted factors, to downregulate the transformation of ADSCs into TAFs, and in upregulating the adipogenic differentiation of ADSCs.

en_US
dc.publisherCurtin Universityen_US
dc.titleImplications of the WNT Signalling Pathway for Adipose-derived Mesenchymal Stem Cells in a Breast Tumour Environmenten_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentSchool of Biomedical Sciencesen_US
curtin.accessStatusOpen accessen_US
curtin.facultyHealth Sciencesen_US


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