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dc.contributor.authorGauri, Bhawna
dc.contributor.supervisorDr Yan Chenen_US
dc.date.accessioned2017-12-06T04:52:35Z
dc.date.available2017-12-06T04:52:35Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.11937/59107
dc.description.abstract

The present research work involves the formulation and development of rivastigmine and coumarin-6 loaded biodegradable Polylactide-co-glycolic acid nanoparticles attached with single and double nasal mucosa/brain targeting ligands. The developed nanocarrier systems were formulated by a solvent evaporation method and have a particle size of 189-242 nm and drug loading of 3.4%. These systems showed sustained drug release and brain targeting ability. When tested on rats via intranasal administration, 2.2 and 3.3 folds increase in brain targeting with single and dual ligands nanoparticles respectively in comparison to the drug solution. Our study supports the use of sustained release nanoparticles with dual ligands, in conjunction with intranasal administration to achieve better brain targeting efficiency.

en_US
dc.publisherCurtin Universityen_US
dc.titleDevelopment and evaluation of an intranasal nanoparticulate formulation for enhanced transport of Rivastigmine into the brainen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentSchool of Pharmacyen_US
curtin.accessStatusFulltext not availableen_US
curtin.facultyHealth Sciencesen_US
dc.date.embargoEnd2022-10-27


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