Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample

Parr, J.; Le Couteur, A.; Baird, G.; Rutter, M.; Pickles, A.; Fombonne, E.; Bailey, A.; Wallace, S.; Wittemeyer, K.; Monaco, A.; Barnby, G.; Bolton, P.; Moore, J.; Murin, M.; McConachie, H.; Berney, T.; Docherty, Z.; Abbs, S.; Ogilvie, C.; Warburton, P.; Lamb, J.; Green, J.; Bolton, B.; Packer, R.; Haracopos, D.; Pedersen, L.; Isager, T.; Brondum-Nielsen, K.; Roge, B.; Tauber, M.; Mantoulan, C.; Poustka, F.; Bölte, Sven; Feineis-Matthews, S.; Rühl, D.; Schmötzer, G.; Poustka, A.; Klauck, S.; Tsiantis, J.; Papanikolaou, K.; Maestrini, E.; Van Engeland, H.; De Jonge, M.; Lord, C.; Corsello, C.; Cook, E.; Salt, J.; Guter, S.; Leventhal, B.; Volkmar, F.; Koenig, K.

doi:10.1007/s10803-010-1055-2

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Authors

Parr, J.

Le Couteur, A.

Baird, G.

Rutter, M.

Pickles, A.

Fombonne, E.

Bailey, A.

Wallace, S.

Wittemeyer, K.

Monaco, A.

Barnby, G.

Bolton, P.

Moore, J.

Murin, M.

McConachie, H.

Berney, T.

Docherty, Z.

Abbs, S.

Ogilvie, C.

Warburton, P.

Lamb, J.

Green, J.

Bolton, B.

Packer, R.

Haracopos, D.

Pedersen, L.

Isager, T.

Brondum-Nielsen, K.

Roge, B.

Tauber, M.

Mantoulan, C.

Poustka, F.

Bölte, Sven

Feineis-Matthews, S.

Rühl, D.

Schmötzer, G.

Poustka, A.

Klauck, S.

Tsiantis, J.

Papanikolaou, K.

Maestrini, E.

Van Engeland, H.

De Jonge, M.

Lord, C.

Corsello, C.

Cook, E.

Salt, J.

Guter, S.

Leventhal, B.

Volkmar, F.

Koenig, K.

Date

2011

Type

Journal Article

Metadata

Show full item record

Citation

Parr, J. and Le Couteur, A. and Baird, G. and Rutter, M. and Pickles, A. and Fombonne, E. and Bailey, A. et al. 2011. Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample. Journal of Autism and Developmental Disorders. 41 (3): pp. 332-340.

Source Title

Journal of Autism and Developmental Disorders

DOI

10.1007/s10803-010-1055-2

ISSN

0162-3257

School

School of Occupational Therapy and Social Work

URI

http://hdl.handle.net/20.500.11937/59318

Collection

Curtin Research Publications

Abstract

The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. © Springer Science+Business Media, LLC 2010.