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dc.contributor.authorParr, J.
dc.contributor.authorLe Couteur, A.
dc.contributor.authorBaird, G.
dc.contributor.authorRutter, M.
dc.contributor.authorPickles, A.
dc.contributor.authorFombonne, E.
dc.contributor.authorBailey, A.
dc.contributor.authorWallace, S.
dc.contributor.authorWittemeyer, K.
dc.contributor.authorMonaco, A.
dc.contributor.authorBarnby, G.
dc.contributor.authorBolton, P.
dc.contributor.authorMoore, J.
dc.contributor.authorMurin, M.
dc.contributor.authorMcConachie, H.
dc.contributor.authorBerney, T.
dc.contributor.authorDocherty, Z.
dc.contributor.authorAbbs, S.
dc.contributor.authorOgilvie, C.
dc.contributor.authorWarburton, P.
dc.contributor.authorLamb, J.
dc.contributor.authorGreen, J.
dc.contributor.authorBolton, B.
dc.contributor.authorPacker, R.
dc.contributor.authorHaracopos, D.
dc.contributor.authorPedersen, L.
dc.contributor.authorIsager, T.
dc.contributor.authorBrondum-Nielsen, K.
dc.contributor.authorRoge, B.
dc.contributor.authorTauber, M.
dc.contributor.authorMantoulan, C.
dc.contributor.authorPoustka, F.
dc.contributor.authorBölte, Sven
dc.contributor.authorFeineis-Matthews, S.
dc.contributor.authorRühl, D.
dc.contributor.authorSchmötzer, G.
dc.contributor.authorPoustka, A.
dc.contributor.authorKlauck, S.
dc.contributor.authorTsiantis, J.
dc.contributor.authorPapanikolaou, K.
dc.contributor.authorMaestrini, E.
dc.contributor.authorVan Engeland, H.
dc.contributor.authorDe Jonge, M.
dc.contributor.authorLord, C.
dc.contributor.authorCorsello, C.
dc.contributor.authorCook, E.
dc.contributor.authorSalt, J.
dc.contributor.authorGuter, S.
dc.contributor.authorLeventhal, B.
dc.contributor.authorVolkmar, F.
dc.contributor.authorKoenig, K.
dc.identifier.citationParr, J. and Le Couteur, A. and Baird, G. and Rutter, M. and Pickles, A. and Fombonne, E. and Bailey, A. et al. 2011. Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample. Journal of Autism and Developmental Disorders. 41 (3): pp. 332-340.

The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. © Springer Science+Business Media, LLC 2010.

dc.publisherSpringer New York LLC
dc.titleEarly developmental regression in autism spectrum disorder: Evidence from an international multiplex sample
dc.typeJournal Article
dcterms.source.titleJournal of Autism and Developmental Disorders
curtin.departmentSchool of Occupational Therapy and Social Work
curtin.accessStatusFulltext not available

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