Novel Key Biofilm-Forming Surface-Associated Polysaccharide and Protein Antigens of Bordetella pertussis and the Comparative Immunoprotective Potential
MetadataShow full item record
Whooping cough has resurged in several countries, despite high vaccine coverage, representing a significant public health concern. Biofilm formation has recently been associated with the pathogenesis of Bordetella pertussis. I showed that vaccination of mice with biofilm and two novel biofilm-upregulated proteins induced Th1 immune responses and protected mice from virulent B. pertussis infection. The study identified a novel role of biofilm and its associated antigens as potential new whooping cough vaccines.
Showing items related by title, author, creator and subject.
Human methicillin-sensitive Staphylococcus aureus biofilms: potential associations with antibiotic resistance persistence and surface polysaccharide antigensBabra, C.; Gogoi Tiwari, Jully; Costantino, Paul; Sunagar, R.; Isloor, S.; Hegde, N.; Mukkur, Trilochan (2013)The development of persistent antibiotic resistance by human methicillin-sensitive Staphylococcus aureus (MSSA) strains and substantial association with poly-N-acetyl glucosamine (PNAG) in biofilms is reported in this ...
The Influence of Prior Modes of Growth, Temperature, Medium, and Substrate Surface on Biofilm Formation by Antibiotic-Resistant Campylobacter jejuniTeh, A.; Lee, S.; Dykes, Gary (2016)Campylobacter jejuni is one of the most common causes of bacterial gastrointestinal food-borne infection worldwide. It has been suggested that biofilm formation may play a role in survival of these bacteria in the ...
Biofilm inhibiting activity of betacyanins from red pitahaya (Hylocereus polyrhizus) and red spinach (Amaranthus dubius) against Staphylococcus aureus and Pseudomonas aeruginosa biofilmsYong, Y.; Dykes, Gary; Lee, S.; Choo, W. (2018)© 2018 The Society for Applied Microbiology Aims: To investigate the biofilm inhibitory activity of betacyanins from red pitahaya (Hylocereus polyrhizus) and red spinach (Amaranthus dubius) against Staphylococcus aureus ...