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dc.contributor.authorDorji
dc.contributor.supervisorDr Ross Grahamen_US
dc.date.accessioned2017-12-18T05:53:16Z
dc.date.available2017-12-18T05:53:16Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.11937/59629
dc.description.abstract

Whooping cough has resurged in several countries, despite high vaccine coverage, representing a significant public health concern. Biofilm formation has recently been associated with the pathogenesis of Bordetella pertussis. I showed that vaccination of mice with biofilm and two novel biofilm-upregulated proteins induced Th1 immune responses and protected mice from virulent B. pertussis infection. The study identified a novel role of biofilm and its associated antigens as potential new whooping cough vaccines.

en_US
dc.publisherCurtin Universityen_US
dc.titleNovel Key Biofilm-Forming Surface-Associated Polysaccharide and Protein Antigens of Bordetella pertussis and the Comparative Immunoprotective Potentialen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentSchool of Biomedical Sciencesen_US
curtin.accessStatusOpen accessen_US
curtin.facultyHealth Sciencesen_US


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