The effect of hydronium ions on the structure of phospholipid membranes
MetadataShow full item record
© 2017 the Owner Societies. This work seeks to identify the mechanisms by which hydronium ions (H 3 O + ) modulate the structure of phospholipid bilayers by studying the interactions of H 3 O + with phospholipids at the molecular level. For this, we carried out multiple microsecond-long unrestrained molecular dynamics (MD) simulations of a POPC bilayer at different H 3 O + concentrations. The results show that H 3 O + accumulates at the membrane surface where it displaces water and forms strong and long-lived hydrogen bonds with the phosphate and carbonyl oxygens in phospholipids. This results in a concentration-dependent reduction of the area per lipid and an increase in bilayer thickness. This study provides an important molecular-level insight into the mechanism of how H 3 O + modulates the structure of biological membranes and is a critical step towards a better understanding of the effect of low pH on mammalian and bacterial membranes.
Showing items related by title, author, creator and subject.
Hughes, Zak; Mancera, Ricardo (2013)ell membrane phospholipid bilayers can be damaged by the large amounts of dimethyl sulphoxide (DMSO) commonly used in cryopreservation. The interaction of DMSO with model bilayers consisting of 1,2-dioleoyl-sn-glycero-3 ...
Acclimation-induced changes in cell membrane composition and influence on cryotolerance of in vitro shoots of native plant speciesFunnekotter, Bryn; Kaczmarczyk, Anja; Turner, S.; Bunn, E.; Zhou, W.; Smith, S.; Flematti, G.; Mancera, Ricardo (2013)Cell membranes are the primary sites of cryopreservation injury and measuring changes to membrane composition arising from cold acclimation may assist with providing a rationale for optimising cryopreservation methods. ...
Polar constituents of oils and bitumens – new applications to Petroleum Geochemistry and (Palaeo)BiogeochemistryHallmann, Christian Olivier Eduard (2008)Polar organic molecules are defined by differences in electronegativity between their atomic constituents and the resulting asymmetrical structures. They represent the basic chemical building blocks of life. Having a ...