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    The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa

    Access Status
    Open access via publisher
    Authors
    Mac Aogáin, M.
    Mooij, M.
    McCarthy, R.
    Plower, E.
    Wang, Y.
    Tian, Z.
    Dobson, A.
    Morrissey, J.
    Adams, C.
    O'Gara, Fergal
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Mac Aogáin, M. and Mooij, M. and McCarthy, R. and Plower, E. and Wang, Y. and Tian, Z. and Dobson, A. et al. 2012. The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa. Microbiology. 158 (10): pp. 2598-2609.
    Source Title
    Microbiology
    DOI
    10.1099/mic.0.058636-0
    ISSN
    1350-0872
    URI
    http://hdl.handle.net/20.500.11937/6140
    Collection
    • Curtin Research Publications
    Abstract

    PyeR (PA4354) is a novel member of the ArsR family of transcriptional regulators and modulates biofilm formation in Pseudomonas aeruginosa. Characterization of this regulator showed that it has negative autoregulatory properties and binds to a palindromic motif conserved among PyeR orthologues. These characteristics are in line with classical ArsR-family regulators, as is the fact that PyeR is part of an operon structure (pyeR-pyeM-xenB). However, PyeR also exhibits some atypical features in comparison with classical members of the ArsR family, as it does not harbour metal-binding motifs and does not appear to be involved in metal perception or resistance. Hence, PyeR belongs to a subgroup of non-classical ArsR-family regulators and is the second ArsR regulator shown to be involved in biofilm formation.

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