Determination of the new anthelmintic monepantel and its sulfone metabolite in milk and muscle using a UHPLC-MS/MS and QuEChERS method
MetadataShow full item record
This is the first paper to report a method for the detection of the new anthelmintic monepantel and its sulfone metabolite in goat's milk and ovine muscle. Samples were extracted and purified using a modified QuEChERS method. A concentration step was included when analyzing in the low Î¼gkg -1 range. Analysis was carried out by ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in a 13min run time using atmospheric pressure electrospray ionisation in the negative mode (ESI - ) and multiple reaction monitoring (MRM) scanning. Monepantel (m/z 472) and monepantel-sulfone (m/z 504) both had product ions at m/z 186 and m/z 166. The method has been single-laboratory validated according to the 2002/657/EC guidelines. The mean recovery in milk was 108 and 106% for monepantel and monepantel-sulfone, respectively. The mean recovery in muscle was 109 and 108% for monepantel and monepantel-sulfone, respectively. The coefficients of variation for the within laboratory repeatability and reproducibility were â‰¤6.4% in milk and â‰¤14.2% in muscle. The decision limits (CCÎ±) in milk were 2.20 and 2.08Î¼gkg -1 for monepantel and monepantel-sulfone, respectively. The decision limits (CCÎ±) in muscle were 771 and 746Î¼gkg -1 for monepantel and monepantel-sulfone, respectively. Â© 2011 Elsevier B.V.
Showing items related by title, author, creator and subject.
McLeod, Gemma; Sherriff, Jill; Nathan, Elizabeth; Hartmann, Peter; Simmer, Karen (2013)Aim: Preterm nutritional audits have previously been conducted using assumed milk composition. We audited protein and energy intakes in the first 28 days of preterm life using both assumed milk composition and milk analysis ...
Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milkSalman, S.; Sy, S.; Ilett, K.; Page-Sharp, Madhu; Paech, M. (2011)Purpose: The aim of this investigation was to demonstrate that nonlinear mixed-effects population pharmacokinetic (PK) modeling can be used to evaluate data from studies of drug transport/excretion into human milk and ...
Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescentsAyonrinde, Oyekoya; Oddy, W.; Adams, L.; Mori, T.; Beilin, L.; de Klerk, N.; Olynyk, John (2016)Background & Aims: The pathway to non-alcoholic fatty liver disease (NAFLD) in adolescents may have its origins in adiposity gains, nutrition and sedentary lifestyle established during childhood. There is inadequate ...