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    Determination of the new anthelmintic monepantel and its sulfone metabolite in milk and muscle using a UHPLC-MS/MS and QuEChERS method

    Access Status
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    Authors
    Kinsella, Brian
    Byrne, P.
    Cantwell, H.
    McCormack, M.
    Furey, A.
    Danaher, M.
    Date
    2011
    Type
    Journal Article
    
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    Citation
    Kinsella, B. and Byrne, P. and Cantwell, H. and McCormack, M. and Furey, A. and Danaher, M. 2011. Determination of the new anthelmintic monepantel and its sulfone metabolite in milk and muscle using a UHPLC-MS/MS and QuEChERS method. Journal of Chromatography B. 879 (31): pp. 3707-3713.
    Source Title
    Journal of Chromatography B
    DOI
    10.1016/j.jchromb.2011.10.011
    ISSN
    1570-0232
    URI
    http://hdl.handle.net/20.500.11937/61682
    Collection
    • Curtin Research Publications
    Abstract

    This is the first paper to report a method for the detection of the new anthelmintic monepantel and its sulfone metabolite in goat's milk and ovine muscle. Samples were extracted and purified using a modified QuEChERS method. A concentration step was included when analyzing in the low μgkg -1 range. Analysis was carried out by ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in a 13min run time using atmospheric pressure electrospray ionisation in the negative mode (ESI - ) and multiple reaction monitoring (MRM) scanning. Monepantel (m/z 472) and monepantel-sulfone (m/z 504) both had product ions at m/z 186 and m/z 166. The method has been single-laboratory validated according to the 2002/657/EC guidelines. The mean recovery in milk was 108 and 106% for monepantel and monepantel-sulfone, respectively. The mean recovery in muscle was 109 and 108% for monepantel and monepantel-sulfone, respectively. The coefficients of variation for the within laboratory repeatability and reproducibility were ≤6.4% in milk and ≤14.2% in muscle. The decision limits (CCα) in milk were 2.20 and 2.08μgkg -1 for monepantel and monepantel-sulfone, respectively. The decision limits (CCα) in muscle were 771 and 746μgkg -1 for monepantel and monepantel-sulfone, respectively. © 2011 Elsevier B.V.

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