Curtin University Homepage
  • Library
  • FAQ
    • Log in

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma

    Access Status
    Open access via publisher
    Authors
    Sethi, G.
    Shanmugam, M.
    Kumar, Alan Prem
    Date
    2017
    Collection
    • Curtin Research Publications
    Type
    Journal Article
    Metadata
    Show full item record
    Abstract

    Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, exhibits elevated lipid accumulation. However, it has not been fully understood how lipid metabolism might be associated with cell cycle regulation in ccRCC. In a recent issue, Lee et al. (Molecular and Cellular Biology (2017) pii: MCB.00265-17) demonstrate that SREBP-1c is up-regulated in ccRCC by ring finger protein 20 (RNF20) down-regulation, leading to aberrant lipid storage and pituitary tumor transforming gene 1 (PTTG1)-dependent cell cycle progression. These findings suggest that SREBP-1c serves as a molecular bridge between lipid metabolism and cell cycle control in ccRCC tumorigenesis.

    Citation
    Sethi, G. and Shanmugam, M. and Kumar, A.P. 2017. SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma. Bioscience Reports. 37 (6).
    Source Title
    Bioscience Reports
    URI
    http://hdl.handle.net/20.500.11937/62753
    DOI
    10.1042/BSR20171270
    Department
    Curtin Medical School

    Related items

    Showing items related by title, author, creator and subject.

    • A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems
      Huang, J.; Mousley, Carl; Dacquay, L.; Maitra, N.; Drin, G.; He, C.; Ridgway, N.; Tripathi, A.; Kennedy, M.; Kennedy, B.; Liu, W.; Baetz, K.; Polymenis, M.; Bankaitis, V. (2018)
      © 2017 Elsevier Inc. Kes1/Osh4 is a member of the conserved, but functionally enigmatic, oxysterol binding protein-related protein (ORP) superfamily that inhibits phosphatidylinositol transfer protein (Sec14)-dependent ...
    • SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma
      Sethi, G.; Shanmugam, M.; Kumar, Alan Prem (2017)
      Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, ...
    • Nutritional and pharmacological regulation of cerebral capillary function
      Pallebage-Gamarallage, Menuka Madhavi Somapala (2012)
      Alzheimer’s disease (AD) is the most common cause of dementia pathologically characterised by neurovascular inflammation, extracellular proteinaceous deposits enriched in amyloid-β (Aβ) and formation of neurofibrillar ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorsTitlesSubjectsDocument TypesThis CollectionIssue DateAuthorsTitlesSubjectsDocument Types

    My Account

    Log in

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Connect with Curtin

    • 
    • 
    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Send FeedbackContact Us
    DSpace software copyright © 2002-2015  DuraSpace