SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma
|dc.contributor.author||Kumar, Alan Prem|
|dc.identifier.citation||Sethi, G. and Shanmugam, M. and Kumar, A.P. 2017. SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma. Bioscience Reports. 37 (6).|
Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, exhibits elevated lipid accumulation. However, it has not been fully understood how lipid metabolism might be associated with cell cycle regulation in ccRCC. In a recent issue, Lee et al. (Molecular and Cellular Biology (2017) pii: MCB.00265-17) demonstrate that SREBP-1c is up-regulated in ccRCC by ring finger protein 20 (RNF20) down-regulation, leading to aberrant lipid storage and pituitary tumor transforming gene 1 (PTTG1)-dependent cell cycle progression. These findings suggest that SREBP-1c serves as a molecular bridge between lipid metabolism and cell cycle control in ccRCC tumorigenesis.
|dc.title||SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma|
|curtin.department||Curtin Medical School|
|curtin.accessStatus||Open access via publisher|
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