SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma
dc.contributor.author | Sethi, G. | |
dc.contributor.author | Shanmugam, M. | |
dc.contributor.author | Kumar, Alan Prem | |
dc.date.accessioned | 2018-02-01T05:25:30Z | |
dc.date.available | 2018-02-01T05:25:30Z | |
dc.date.created | 2018-02-01T04:49:23Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Sethi, G. and Shanmugam, M. and Kumar, A.P. 2017. SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma. Bioscience Reports. 37 (6). | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/62753 | |
dc.identifier.doi | 10.1042/BSR20171270 | |
dc.description.abstract |
Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, exhibits elevated lipid accumulation. However, it has not been fully understood how lipid metabolism might be associated with cell cycle regulation in ccRCC. In a recent issue, Lee et al. (Molecular and Cellular Biology (2017) pii: MCB.00265-17) demonstrate that SREBP-1c is up-regulated in ccRCC by ring finger protein 20 (RNF20) down-regulation, leading to aberrant lipid storage and pituitary tumor transforming gene 1 (PTTG1)-dependent cell cycle progression. These findings suggest that SREBP-1c serves as a molecular bridge between lipid metabolism and cell cycle control in ccRCC tumorigenesis. | |
dc.title | SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma | |
dc.type | Journal Article | |
dcterms.source.volume | 37 | |
dcterms.source.number | 6 | |
dcterms.source.issn | 0144-8463 | |
dcterms.source.title | Bioscience Reports | |
curtin.department | Curtin Medical School | |
curtin.accessStatus | Open access via publisher |
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