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    ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and C-Myc to reduce breast cancer proliferation

    Access Status
    Open access via publisher
    Authors
    Yuan, Y.
    Anbalagan, D.
    Lee, L.
    Samy, R.
    Shanmugam, M.
    Kumar, Alan Prem
    Sethi, G.
    Lobie, P.
    Lim, L.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Yuan, Y. and Anbalagan, D. and Lee, L. and Samy, R. and Shanmugam, M. and Kumar, A.P. and Sethi, G. et al. 2016. ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and C-Myc to reduce breast cancer proliferation. Oncotarget. 7 (19): pp. 27007-27020.
    Source Title
    Oncotarget
    DOI
    10.18632/oncotarget.8875
    ISSN
    1949-2553
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/62958
    Collection
    • Curtin Research Publications
    Abstract

    MiRNAs are endogenous ~22 nt RNAs which play critical regulatory roles in a wide range of biological and pathological processes, which can act as oncogenes or tumor suppressor genes depending on their target genes. We have recently shown that ANXA1 inhibits the expression of miRNAs including miR196a. Here, we show that miR196a was highly expressed in ER+ MCF-7 breast cancer cells when compared to normal mammary gland cells, with expression levels negatively correlating to ANXA1. ANXA1 inhibits the biogenesis of oncogenic miR-196a by suppressing primarymiR196a indirectly through the stimulation of c-myc and NFkB expression and activity in breast cancer cells. In a negative feedback loop, miR-196a directly inhibits ANXA1 and enhances breast cancer cell proliferation in vitro. Finally, miR196a promotes breast tumor growth in vivo. This study reports a novel regulatory circuit between ANXA1, NF-kB, c-myc and miR-196a which regulates breast cancer cell proliferation and tumor growth.

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