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dc.contributor.authorNastiti, Christofori
dc.contributor.authorPonto, Thellie
dc.contributor.authorAbd, E.
dc.contributor.authorGrice, J.
dc.contributor.authorBenson, Heather
dc.contributor.authorRoberts, M.
dc.date.accessioned2018-02-06T06:15:22Z
dc.date.available2018-02-06T06:15:22Z
dc.date.created2018-02-06T05:49:47Z
dc.date.issued2017
dc.identifier.citationNastiti, C. and Ponto, T. and Abd, E. and Grice, J. and Benson, H. and Roberts, M. 2017. Topical nano and microemulsions for skin delivery. Pharmaceutics. 9 (4): 37.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/63140
dc.identifier.doi10.3390/pharmaceutics9040037
dc.description.abstract

© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME a nd NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation.

dc.publisherMDPIAG
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleTopical nano and microemulsions for skin delivery
dc.typeJournal Article
dcterms.source.volume9
dcterms.source.number4
dcterms.source.issn1999-4923
dcterms.source.titlePharmaceutics
curtin.departmentSchool of Pharmacy
curtin.accessStatusOpen access


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