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    Identification of common variants associated with human hippocampal and intracranial volumes

    Access Status
    Fulltext not available
    Authors
    Stein, J.
    Medland, S.
    Vasquez, A.
    Hibar, D.
    Senstad, R.
    Winkler, A.
    Toro, R.
    Appel, K.
    Bartecek, R.
    Bergmann, O.
    Bernard, M.
    Brown, A.
    Cannon, D.
    Chakravarty, M.
    Christoforou, A.
    Domin, M.
    Grimm, O.
    Hollinshead, M.
    Holmes, A.
    Homuth, G.
    Hottenga, J.
    Langan, C.
    Lopez, L.
    Hansell, N.
    Hwang, K.
    Kim, S.
    Laje, G.
    Lee, P.
    Liu, X.
    Loth, E.
    Lourdusamy, A.
    Mattingsdal, M.
    Mohnke, S.
    Maniega, S.
    Nho, K.
    Nugent, A.
    O'Brien, C.
    Papmeyer, M.
    Putz, B.
    Ramasamy, A.
    Rasmussen, J.
    Rijpkema, M.
    Risacher, S.
    Roddey, J.
    Rose, E.
    Ryten, M.
    Shen, L.
    Sprooten, E.
    Strengman, E.
    Teumer, A.
    Trabzuni, D.
    Turner, J.
    van Eijk, K.
    van Erp, T.
    van Tol, M.
    Wittfeld, K.
    Wolf, C.
    Woudstra, S.
    Aleman, A.
    Alhusaini, S.
    Almasy, L.
    Binder, E.
    Brohawn, D.
    Cantor, R.
    Carless, M.
    Corvin, A.
    Czisch, M.
    Curran, J.
    Davies, G.
    de Almeida, M.
    Delanty, N.
    Depondt, C.
    Duggirala, R.
    Dyer, T.
    Erk, S.
    Fagerness, J.
    Fox, P.
    Freimer, N.
    Gill, M.
    Goering, H.
    Hagler, D.
    Hoehn, D.
    Holsboer, F.
    Hoogman, M.
    Hosten, N.
    Jahanshad, N.
    Johnson, M.
    Kasperaviciute, D.
    Kent, J.
    Kochunov, P.
    Lancaster, J.
    Lawrie, S.
    Liewald, D.
    Mandl, R.
    Matarin, M.
    Mattheisen, M.
    Meisenzahl, E.
    Melle, I.
    Moses, Eric
    Muehleisen, T.
    Nauck, M.
    Noethen, M.
    Olvera, R.
    Pandolfo, M.
    Pike, G.
    Puls, R.
    Reinvang, I.
    Renteria, M.
    Rietschel, M.
    Roffman, J.
    Royle, N.
    Rujescu, D.
    Savitz, J.
    Schnack, H.
    Schnell, K.
    Seiferth, N.
    Smith, C.
    Steen, V.
    Hernandez, M.
    Van den Heuvel, M.
    van der Wee, N.
    Van Haren, N.
    Veltman, J.
    Voelzke, H.
    Walker, R.
    Westlye, L.
    Whelan, C.
    Agartz, I.
    Boomsma, D.
    Cavalleri, G.
    Dale, A.
    Djurovic, S.
    Drevets, W.
    Hagoort, P.
    Hall, J.
    Heinz, A.
    Jack, C.
    Foroud, T.
    Le Hellard, S.
    Macciardi, F.
    Montgomery, G.
    Poline, J.
    Porteous, D.
    Sisodiya, S.
    Starr, J.
    Sussmann, J.
    Toga, A.
    Veltman, D.
    Walter, H.
    Weiner, M.
    Bis, J.
    Ikram, M.
    Smith, A.
    Gudnason, V.
    Tzourio, C.
    Vernooij, M.
    Launer, L.
    DeCarli, C.
    Seshadri, S.
    Andreassen, O.
    Apostolova, L.
    Bastin, M.
    Blangero, J.
    Brunner, H.
    Buckner, R.
    Cichon, S.
    Coppola, G.
    de Zubicaray, G.
    Deary, I.
    Donohoe, G.
    de Geus, E.
    Espeseth, T.
    Fernandez, G.
    Glahn, D.
    Grabe, H.
    Hardy, J.
    Pol, H.
    Jenkinson, M.
    Kahn, R.
    McDonald, C.
    McIntosh, A.
    McMahon, F.
    McMahon, K.
    Meyer-Lindenberg, A.
    Morris, D.
    Mueller-Myhsok, B.
    Nichols, T.
    Ophoff, R.
    Paus, T.
    Pausova, Z.
    Penninx, B.
    Potkin, S.
    Saemann, P.
    Saykin, A.
    Schumann, G.
    Smoller, J.
    Wardlaw, J.
    Weale, M.
    Martin, N.
    Franke, B.
    Wright, M.
    Thompson, P.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Stein, J. and Medland, S. and Vasquez, A. and Hibar, D. and Senstad, R. and Winkler, A. and Toro, R. et al. 2012. Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics. 44 (5): pp. 552-561.
    Source Title
    Nature Genetics
    DOI
    10.1038/ng.2250
    ISSN
    1061-4036
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/66466
    Collection
    • Curtin Research Publications
    Abstract

    Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10 -16) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10 -12). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10 -7). © 2012 Nature America, Inc. All rights reserved.

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