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dc.contributor.authorStein, J.
dc.contributor.authorMedland, S.
dc.contributor.authorVasquez, A.
dc.contributor.authorHibar, D.
dc.contributor.authorSenstad, R.
dc.contributor.authorWinkler, A.
dc.contributor.authorToro, R.
dc.contributor.authorAppel, K.
dc.contributor.authorBartecek, R.
dc.contributor.authorBergmann, O.
dc.contributor.authorBernard, M.
dc.contributor.authorBrown, A.
dc.contributor.authorCannon, D.
dc.contributor.authorChakravarty, M.
dc.contributor.authorChristoforou, A.
dc.contributor.authorDomin, M.
dc.contributor.authorGrimm, O.
dc.contributor.authorHollinshead, M.
dc.contributor.authorHolmes, A.
dc.contributor.authorHomuth, G.
dc.contributor.authorHottenga, J.
dc.contributor.authorLangan, C.
dc.contributor.authorLopez, L.
dc.contributor.authorHansell, N.
dc.contributor.authorHwang, K.
dc.contributor.authorKim, S.
dc.contributor.authorLaje, G.
dc.contributor.authorLee, P.
dc.contributor.authorLiu, X.
dc.contributor.authorLoth, E.
dc.contributor.authorLourdusamy, A.
dc.contributor.authorMattingsdal, M.
dc.contributor.authorMohnke, S.
dc.contributor.authorManiega, S.
dc.contributor.authorNho, K.
dc.contributor.authorNugent, A.
dc.contributor.authorO'Brien, C.
dc.contributor.authorPapmeyer, M.
dc.contributor.authorPutz, B.
dc.contributor.authorRamasamy, A.
dc.contributor.authorRasmussen, J.
dc.contributor.authorRijpkema, M.
dc.contributor.authorRisacher, S.
dc.contributor.authorRoddey, J.
dc.contributor.authorRose, E.
dc.contributor.authorRyten, M.
dc.contributor.authorShen, L.
dc.contributor.authorSprooten, E.
dc.contributor.authorStrengman, E.
dc.contributor.authorTeumer, A.
dc.contributor.authorTrabzuni, D.
dc.contributor.authorTurner, J.
dc.contributor.authorvan Eijk, K.
dc.contributor.authorvan Erp, T.
dc.contributor.authorvan Tol, M.
dc.contributor.authorWittfeld, K.
dc.contributor.authorWolf, C.
dc.contributor.authorWoudstra, S.
dc.contributor.authorAleman, A.
dc.contributor.authorAlhusaini, S.
dc.contributor.authorAlmasy, L.
dc.contributor.authorBinder, E.
dc.contributor.authorBrohawn, D.
dc.contributor.authorCantor, R.
dc.contributor.authorCarless, M.
dc.contributor.authorCorvin, A.
dc.contributor.authorCzisch, M.
dc.contributor.authorCurran, J.
dc.contributor.authorDavies, G.
dc.contributor.authorde Almeida, M.
dc.contributor.authorDelanty, N.
dc.contributor.authorDepondt, C.
dc.contributor.authorDuggirala, R.
dc.contributor.authorDyer, T.
dc.contributor.authorErk, S.
dc.contributor.authorFagerness, J.
dc.contributor.authorFox, P.
dc.contributor.authorFreimer, N.
dc.contributor.authorGill, M.
dc.contributor.authorGoering, H.
dc.contributor.authorHagler, D.
dc.contributor.authorHoehn, D.
dc.contributor.authorHolsboer, F.
dc.contributor.authorHoogman, M.
dc.contributor.authorHosten, N.
dc.contributor.authorJahanshad, N.
dc.contributor.authorJohnson, M.
dc.contributor.authorKasperaviciute, D.
dc.contributor.authorKent, J.
dc.contributor.authorKochunov, P.
dc.contributor.authorLancaster, J.
dc.contributor.authorLawrie, S.
dc.contributor.authorLiewald, D.
dc.contributor.authorMandl, R.
dc.contributor.authorMatarin, M.
dc.contributor.authorMattheisen, M.
dc.contributor.authorMeisenzahl, E.
dc.contributor.authorMelle, I.
dc.contributor.authorMoses, Eric
dc.contributor.authorMuehleisen, T.
dc.contributor.authorNauck, M.
dc.contributor.authorNoethen, M.
dc.contributor.authorOlvera, R.
dc.contributor.authorPandolfo, M.
dc.contributor.authorPike, G.
dc.contributor.authorPuls, R.
dc.contributor.authorReinvang, I.
dc.contributor.authorRenteria, M.
dc.contributor.authorRietschel, M.
dc.contributor.authorRoffman, J.
dc.contributor.authorRoyle, N.
dc.contributor.authorRujescu, D.
dc.contributor.authorSavitz, J.
dc.contributor.authorSchnack, H.
dc.contributor.authorSchnell, K.
dc.contributor.authorSeiferth, N.
dc.contributor.authorSmith, C.
dc.contributor.authorSteen, V.
dc.contributor.authorHernandez, M.
dc.contributor.authorVan den Heuvel, M.
dc.contributor.authorvan der Wee, N.
dc.contributor.authorVan Haren, N.
dc.contributor.authorVeltman, J.
dc.contributor.authorVoelzke, H.
dc.contributor.authorWalker, R.
dc.contributor.authorWestlye, L.
dc.contributor.authorWhelan, C.
dc.contributor.authorAgartz, I.
dc.contributor.authorBoomsma, D.
dc.contributor.authorCavalleri, G.
dc.contributor.authorDale, A.
dc.contributor.authorDjurovic, S.
dc.contributor.authorDrevets, W.
dc.contributor.authorHagoort, P.
dc.contributor.authorHall, J.
dc.contributor.authorHeinz, A.
dc.contributor.authorJack, C.
dc.contributor.authorForoud, T.
dc.contributor.authorLe Hellard, S.
dc.contributor.authorMacciardi, F.
dc.contributor.authorMontgomery, G.
dc.contributor.authorPoline, J.
dc.contributor.authorPorteous, D.
dc.contributor.authorSisodiya, S.
dc.contributor.authorStarr, J.
dc.contributor.authorSussmann, J.
dc.contributor.authorToga, A.
dc.contributor.authorVeltman, D.
dc.contributor.authorWalter, H.
dc.contributor.authorWeiner, M.
dc.contributor.authorBis, J.
dc.contributor.authorIkram, M.
dc.contributor.authorSmith, A.
dc.contributor.authorGudnason, V.
dc.contributor.authorTzourio, C.
dc.contributor.authorVernooij, M.
dc.contributor.authorLauner, L.
dc.contributor.authorDeCarli, C.
dc.contributor.authorSeshadri, S.
dc.contributor.authorAndreassen, O.
dc.contributor.authorApostolova, L.
dc.contributor.authorBastin, M.
dc.contributor.authorBlangero, J.
dc.contributor.authorBrunner, H.
dc.contributor.authorBuckner, R.
dc.contributor.authorCichon, S.
dc.contributor.authorCoppola, G.
dc.contributor.authorde Zubicaray, G.
dc.contributor.authorDeary, I.
dc.contributor.authorDonohoe, G.
dc.contributor.authorde Geus, E.
dc.contributor.authorEspeseth, T.
dc.contributor.authorFernandez, G.
dc.contributor.authorGlahn, D.
dc.contributor.authorGrabe, H.
dc.contributor.authorHardy, J.
dc.contributor.authorPol, H.
dc.contributor.authorJenkinson, M.
dc.contributor.authorKahn, R.
dc.contributor.authorMcDonald, C.
dc.contributor.authorMcIntosh, A.
dc.contributor.authorMcMahon, F.
dc.contributor.authorMcMahon, K.
dc.contributor.authorMeyer-Lindenberg, A.
dc.contributor.authorMorris, D.
dc.contributor.authorMueller-Myhsok, B.
dc.contributor.authorNichols, T.
dc.contributor.authorOphoff, R.
dc.contributor.authorPaus, T.
dc.contributor.authorPausova, Z.
dc.contributor.authorPenninx, B.
dc.contributor.authorPotkin, S.
dc.contributor.authorSaemann, P.
dc.contributor.authorSaykin, A.
dc.contributor.authorSchumann, G.
dc.contributor.authorSmoller, J.
dc.contributor.authorWardlaw, J.
dc.contributor.authorWeale, M.
dc.contributor.authorMartin, N.
dc.contributor.authorFranke, B.
dc.contributor.authorWright, M.
dc.contributor.authorThompson, P.
dc.date.accessioned2018-04-30T02:40:51Z
dc.date.available2018-04-30T02:40:51Z
dc.date.created2018-04-16T07:41:31Z
dc.date.issued2012
dc.identifier.citationStein, J. and Medland, S. and Vasquez, A. and Hibar, D. and Senstad, R. and Winkler, A. and Toro, R. et al. 2012. Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics. 44 (5): pp. 552-561.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/66466
dc.identifier.doi10.1038/ng.2250
dc.description.abstract

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10 -16) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10 -12). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10 -7). © 2012 Nature America, Inc. All rights reserved.

dc.publisherNature Publishing Group
dc.titleIdentification of common variants associated with human hippocampal and intracranial volumes
dc.typeJournal Article
dcterms.source.volume44
dcterms.source.number5
dcterms.source.startPage552
dcterms.source.endPage561
dcterms.source.issn1061-4036
dcterms.source.titleNature Genetics
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusFulltext not available


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