Show simple item record

dc.contributor.authorOlaithe, M.
dc.contributor.authorSkinner, T.
dc.contributor.authorHillman, D.
dc.contributor.authorEastwood, Peter
dc.contributor.authorBucks, R.
dc.identifier.citationOlaithe, M. and Skinner, T. and Hillman, D. and Eastwood, P. and Bucks, R. 2015. Cognition and nocturnal disturbance in OSA: the importance of accounting for age and premorbid intelligence. Sleep and Breathing. 19 (1): pp. 221-230.

© 2014, Springer-Verlag Berlin Heidelberg. Introduction: Obstructive sleep apnea (OSA) is a common disorder that is associated with impaired attention, memory and executive function. However, the mechanisms underlying such dysfunction are unclear. To determine the influence of sleep fragmentation and hypoxia, this study examined the effect of sleep fragmentation and hypoxia on cognition in OSA, while controlling for potentially confounding variables including sleepiness, age and premorbid intelligence. Method: Participants with and without OSA (N = 150) were recruited from the general community and a tertiary hospital sleep clinic. All underwent comprehensive, laboratory-based polysomnography (PSG) and completed assessments of cognition including attention, short- and long-term memory and executive function. Structural equation modelling (SEM) was used to construct a theoretically-driven model to examine the relationships between hypoxia and sleep fragmentation, and cognitive function. Results: Although after controlling for IQ, increased sleep disturbance was a significant predictor of decreased attention (p = 0.04) and decreased executive function (p = 0.05), controlling for age removes these significant relationships. No significant predictors of memory function were found. Conclusions: The mechanisms underlying the effects of OSA on cognition remain to be defined. Implications are discussed in light of these findings.

dc.titleCognition and nocturnal disturbance in OSA: the importance of accounting for age and premorbid intelligence
dc.typeJournal Article
dcterms.source.titleSleep and Breathing
curtin.departmentSchool of Physiotherapy and Exercise Science
curtin.accessStatusFulltext not available

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record