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    Doxorubicin, mesenchymal stem cell toxicity and antitumour activity: implications for clinical use

    Access Status
    Fulltext not available
    Authors
    Baxter-Holland, M.
    Dass, Crispin
    Date
    2018
    Type
    Journal Article
    
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    Citation
    Baxter-Holland, M. and Dass, C. 2018. Doxorubicin, mesenchymal stem cell toxicity and antitumour activity: implications for clinical use. Journal of Pharmacy and Pharmacology. 70 (3): pp. 320-327.
    Source Title
    Journal of Pharmacy and Pharmacology
    DOI
    10.1111/jphp.12869
    ISSN
    0022-3573
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/67187
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Royal Pharmaceutical Society Objectives: The use of doxorubicin, an antineoplastic medication used for the treatment of cancers via mechanisms that prevent replication of cells or lead to their death, can result in damage to healthy cells as well as malignant. Among the affected cells are mesenchymal stem cells (MSCs), which are involved in the maintenance and repair of tissues in the body. This review explores the mechanisms of biological effects and damage attributed to doxorubicin on MSCs. The PubMed database was used as a source of literature for this review. Key findings: Doxorubicin has the potential to lead to significant and irreversible damage to the human bone marrow environment, including MSCs. The primary known mechanism of these changes is through free radical damage and activation of apoptotic pathways. The presence of MSCs in culture or in vivo appears to either suppress or promote tumour growth. Interactions between doxorubicin and MSCs have the potential to increase chemotherapy resistance. Summary: Doxorubicin-induced damage to MSCs is of concern clinically. However, MSCs also have been associated with resistance of tumour cells to drugs including doxorubicin. Further studies, particularly in vivo, are needed to provide consistent results of how the doxorubicin-induced changes to MSCs affect treatment and patient health.

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