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    The effect of temazepam on assessment of severity of obstructive sleep apnea by polysomnography

    Access Status
    Fulltext not available
    Authors
    Walsh, J.
    Visser, C.
    Maddison, K.
    Bharat, C.
    Hillman, D.
    Eastwood, Peter
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Walsh, J. and Visser, C. and Maddison, K. and Bharat, C. and Hillman, D. and Eastwood, P. 2018. The effect of temazepam on assessment of severity of obstructive sleep apnea by polysomnography. Sleep and Breathing: pp. 1-8.
    Source Title
    Sleep and Breathing
    DOI
    10.1007/s11325-018-1653-3
    ISSN
    1520-9512
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/67245
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Springer International Publishing AG, part of Springer Nature Purpose: To determine the effect of temazepam on assessment of the severity of obstructive sleep apnea (OSA) by polysomnography (PSG). Methods: Analysis of diagnostic laboratory-PSG studies was performed in OSA patients who were administered temazepam (10 mg) to facilitate sleep (“temazepam group”, n = 73) and in OSA patients (matched for age, gender, body mass index and study date) in whom temazepam was not administered (“control group”, n = 73). Sleep- and respiratory-related variables were compared between the groups for the (i) first 3 h of study following temazepam in the temazepam group (when peak blood concentration is expected) or following lights out in the control group, and (ii) entire study duration. Results: Within the first 3 h, no differences in sleep-related variables were observed between the groups. Over the entire study duration, the temazepam group had a reduced total sleep time compared to the control group, likely due to the overnight sleep difficulties that led to its use. Whether measured during the first 3 h of study or over the entire study duration, no significant differences were detected between the groups for any respiratory-related variable, including apnea hypopnea index, arousal index, oxygen desaturation, apnea index, hypopnea index, and event duration. When patients were considered in terms of OSA severity, decreased arousal index was noted in the temazepam group over the entire study duration, but only in those with severe OSA. Conclusion: Oral administration of 10 mg of temazepam during the course of PSG does not systematically affect assessment of the severity of OSA by PSG.

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