Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Epidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010–2013

    Access Status
    Fulltext not available
    Authors
    Chang, Y.
    Coombs, Geoffrey
    Ling, T.
    Balaji, V.
    Rodrigues, C.
    Mikamo, H.
    Kim, M.
    Rajasekaram, D.
    Mendoza, M.
    Tan, T.
    Kiratisin, P.
    Ni, Y.
    Barry, W.
    Xu, Y.
    Chen, Y.
    Hsueh, P.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Chang, Y. and Coombs, G. and Ling, T. and Balaji, V. and Rodrigues, C. and Mikamo, H. and Kim, M. et al. 2017. Epidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010–2013. International Journal of Antimicrobial Agents. 49 (6): pp. 734-739.
    Source Title
    International Journal of Antimicrobial Agents
    DOI
    10.1016/j.ijantimicag.2017.01.030
    ISSN
    0924-8579
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/67579
    Collection
    • Curtin Research Publications
    Abstract

    This study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of Gram-negative bacilli (GNB) isolated from intra-abdominal infections (IAIs) in the Asia-Pacific region (APR) from 2010–2013. A total of 17 350 isolates were collected from 54 centres in 13 countries in the APR. The three most commonly isolated GNB were Escherichia coli (46.1%), Klebsiella pneumoniae (19.3%) and Pseudomonas aeruginosa (9.8%). Overall, the rates of extended-spectrum β-lactamase (ESBL)-producing E. coli and K. pneumoniae were 38.2% and 24.3%, respectively, and they were highest in China (66.6% and 38.7%, respectively), Thailand (49.8% and 36.5%, respectively) and Vietnam (47.9% and 30.4%, respectively). During 2010–2013, the rates of ESBL-producing E. coli and K. pneumoniae isolates causing community-associated (CA) IAIs (collected <48 h after admission) were 26.0% and 13.5%, respectively, and those causing hospital-associated (HA) IAIs were 48.0% and 30.6%, respectively. Amikacin, ertapenem and imipenem were the most effective agents against ESBL-producing isolates. Piperacillin/tazobactam displayed good in vitro activity (91.4%) against CA ESBL-producing E. coli. For other commonly isolated Enterobacteriaceae, fluoroquinolones, cefepime and carbapenems exhibited better in vitro activities than third-generation cephalosporins. Amikacin possessed high in vitro activity against all GNB isolates (>80%) causing IAIs, except for Acinetobacter calcoaceticus–baumannii (ACB) complex (30.9% for HA-IAI isolates). All of the antimicrobial agents tested exhibited <45% in vitro activity against ACB complex. Antimicrobial resistance is a persistent threat in the APR and continuous monitoring of evolutionary trends in the susceptibility patterns of GNB causing IAIs in this region is mandatory.

    Related items

    Showing items related by title, author, creator and subject.

    • Epidemiology and antimicrobial susceptibility profiles of pathogens causing urinary tract infections in the Asia-Pacific region: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2010-2013
      Jean, S.; Coombs, Geoffrey; Ling, T.; Balaji, V.; Rodrigues, C.; Mikamo, H.; Kim, M.; Rajasekaram, D.; Mendoza, M.; Tan, T.; Kiratisin, P.; Ni, Y.; Weinman, B.; Xu, Y.; Hsueh, P. (2016)
      A total of 9599 isolates of Gram-negative bacteria (GNB) causing urinary tract infections (UTIs) were collected from 60 centres in 13 countries in the Asia-Pacific region from 2010-2013. These isolates comprised ...
    • Expression and modulation of tissue factor and tissue factor pathway inhibitor in an endothelial cell based model
      Ellery, Paul E. R. (2008)
      Haemostasis is a complex physiological process involving cellular and plasma protein components that interact to keep the blood fluid under normal conditions and prevent blood loss after vessel injury by promoting clot ...
    • Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008–14: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)
      Jean, S.; Hsueh, P.; Korman, T.; Ellem, J.; George, N.; Coombs, Geoffrey; Ling, T.; Tsang, O.; Balaji, V.; Mikamo, H.; Kusachi, S.; Mizutani, T.; Kim, M.; Bae, I.; Umur, N.; Rajasekaram, D.; Taylor, S.; Roberts, S.; van der Werff, K.; Drinkovic, D.; Lagamayo, E.; Mendoza, M.; Tan, T.; Krishnan, P.; Wang, E.; Lu, P.; Liu, C.; Chuang, K.; Yu, K.; Chen, Y.; Lu, M.; Panthuwong, S.; Kiratisin, P.; Phoung, N.; Phuong, D.; Van, N.; Nga, T. (2017)
      Objectives: To investigate the antimicrobial resistance and assess the molecular characteristics of β-lactamases (ESBLs, AmpC β-lactamases and carbapenemases) among Enterobacteriaceae isolates that caused intra-abdominal ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.