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dc.contributor.authorChang, Y.
dc.contributor.authorCoombs, Geoffrey
dc.contributor.authorLing, T.
dc.contributor.authorBalaji, V.
dc.contributor.authorRodrigues, C.
dc.contributor.authorMikamo, H.
dc.contributor.authorKim, M.
dc.contributor.authorRajasekaram, D.
dc.contributor.authorMendoza, M.
dc.contributor.authorTan, T.
dc.contributor.authorKiratisin, P.
dc.contributor.authorNi, Y.
dc.contributor.authorBarry, W.
dc.contributor.authorXu, Y.
dc.contributor.authorChen, Y.
dc.contributor.authorHsueh, P.
dc.identifier.citationChang, Y. and Coombs, G. and Ling, T. and Balaji, V. and Rodrigues, C. and Mikamo, H. and Kim, M. et al. 2017. Epidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010–2013. International Journal of Antimicrobial Agents. 49 (6): pp. 734-739.

This study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of Gram-negative bacilli (GNB) isolated from intra-abdominal infections (IAIs) in the Asia-Pacific region (APR) from 2010–2013. A total of 17 350 isolates were collected from 54 centres in 13 countries in the APR. The three most commonly isolated GNB were Escherichia coli (46.1%), Klebsiella pneumoniae (19.3%) and Pseudomonas aeruginosa (9.8%). Overall, the rates of extended-spectrum β-lactamase (ESBL)-producing E. coli and K. pneumoniae were 38.2% and 24.3%, respectively, and they were highest in China (66.6% and 38.7%, respectively), Thailand (49.8% and 36.5%, respectively) and Vietnam (47.9% and 30.4%, respectively). During 2010–2013, the rates of ESBL-producing E. coli and K. pneumoniae isolates causing community-associated (CA) IAIs (collected <48 h after admission) were 26.0% and 13.5%, respectively, and those causing hospital-associated (HA) IAIs were 48.0% and 30.6%, respectively. Amikacin, ertapenem and imipenem were the most effective agents against ESBL-producing isolates. Piperacillin/tazobactam displayed good in vitro activity (91.4%) against CA ESBL-producing E. coli. For other commonly isolated Enterobacteriaceae, fluoroquinolones, cefepime and carbapenems exhibited better in vitro activities than third-generation cephalosporins. Amikacin possessed high in vitro activity against all GNB isolates (>80%) causing IAIs, except for Acinetobacter calcoaceticus–baumannii (ACB) complex (30.9% for HA-IAI isolates). All of the antimicrobial agents tested exhibited <45% in vitro activity against ACB complex. Antimicrobial resistance is a persistent threat in the APR and continuous monitoring of evolutionary trends in the susceptibility patterns of GNB causing IAIs in this region is mandatory.

dc.publisherElsevier Science
dc.titleEpidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010–2013
dc.typeJournal Article
dcterms.source.titleInternational Journal of Antimicrobial Agents
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusFulltext not available

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