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    Cyclometalated iridium(III) complexes for life science

    265199.pdf (1.776Mb)
    Access Status
    Open access
    Authors
    Caporale, C.
    Massi, Massimiliano
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Caporale, C. and Massi, M. 2018. Cyclometalated iridium(III) complexes for life science. Coordination Chemistry Reviews. 363: pp. 71-91.
    Source Title
    Coordination Chemistry Reviews
    DOI
    10.1016/j.ccr.2018.02.006
    ISSN
    0010-8545
    School
    School of Molecular and Life Sciences (MLS)
    Funding and Sponsorship
    http://purl.org/au-research/grants/arc/FT130100033
    URI
    http://hdl.handle.net/20.500.11937/67700
    Collection
    • Curtin Research Publications
    Abstract

    Photoluminescent cyclometalated iridium(III) complexes are now a well established class of organometallic compounds with advantageous potential applications in biology and life science. While these complexes, along with other luminescent transition metals and lanthanoid complexes, were initially proposed as alternative markers to organic fluorophores in the staining of cells, it is now evident that their specific biological behavior makes this class of compounds useful in broader areas of life science such as imaging, sensing and therapy. The critical factors for the effective design of cyclometalated iridium(III) complexes with specific biological properties are still rather difficult to rationalize, and often mainly rely of aspects such as the intrinsic charge of the complex, its lipophilicity and its aqueous solubility. This review overviews the area of cyclometalated iridium(III) complexes in biology, with an emphasis on comparing the various conditions that these compounds have been assessed for their biological potential, such as the specific tested cells lines, concentration of internalization, incubation time, and mechanism of cellular entrance.

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