Cyclometalated iridium(III) complexes for life science
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Photoluminescent cyclometalated iridium(III) complexes are now a well established class of organometallic compounds with advantageous potential applications in biology and life science. While these complexes, along with other luminescent transition metals and lanthanoid complexes, were initially proposed as alternative markers to organic fluorophores in the staining of cells, it is now evident that their specific biological behavior makes this class of compounds useful in broader areas of life science such as imaging, sensing and therapy. The critical factors for the effective design of cyclometalated iridium(III) complexes with specific biological properties are still rather difficult to rationalize, and often mainly rely of aspects such as the intrinsic charge of the complex, its lipophilicity and its aqueous solubility. This review overviews the area of cyclometalated iridium(III) complexes in biology, with an emphasis on comparing the various conditions that these compounds have been assessed for their biological potential, such as the specific tested cells lines, concentration of internalization, incubation time, and mechanism of cellular entrance.
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Caporale, Chiara (2018)In this research, a series of iridium(III) tetrazolato complexes were synthesised and their photophysical and biological properties investigated. Both the cyclometalated and the ancillary ligands were systematically ...
Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live CellsCaporale, C.; Bader, C.; Sorvina, A.; Magee, K.; Skelton, B.; Gillam, T.; Wright, P.; Raiteri, Paolo; Stagni, S.; Morrison, J.; Plush, S.; Brooks, D.; Massi, Massimiliano (2017)A family of five neutral cyclometalated iridium(III) tetrazolato complexes and their methylated cationic analogues have been synthesised and characterised. The complexes are distinguished by variations of the substituents ...
Sorvina, A.; Bader, C.; Darby, J.; Lock, M.; Soo, J.; Johnson, I.; Caporale, Chiara; Voelcker, N.; Stagni, S.; Massi, Massimiliano; Morrison, J.; Plush, S.; Brooks, D. (2018)© 2018 The Author(s). Mitochondrial morphology is important for the function of this critical organelle and, accordingly, altered mitochondrial structure is exhibited in many pathologies. Imaging of mitochondria can ...