Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Molecular actions of Vitamin D in reproductive cell biology

    Access Status
    Open access via publisher
    Authors
    Keane, Kevin
    Cruzat, V.
    Calton, E.
    Hart, P.
    Soares, M.
    Newsholme, P.
    Yovich, J.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Keane, K. and Cruzat, V. and Calton, E. and Hart, P. and Soares, M. and Newsholme, P. and Yovich, J. 2017. Molecular actions of Vitamin D in reproductive cell biology. Reproduction. 153 (1): pp. R29-R42.
    Source Title
    Reproduction
    DOI
    10.1530/REP-16-0386
    ISSN
    1470-1626
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/6831
    Collection
    • Curtin Research Publications
    Abstract

    Vitamin D (VitD) is an important secosteroid and has attracted attention in several areas of research due to common VitD deficiency in the population, and its potential to regulate molecular pathways related to chronic and inflammatory diseases. VitD metabolites and the VitD receptor (VDR) influence many tissues including those of the reproductive system. VDR expression has been demonstrated in various cell types of the male reproductive tract, including spermatozoa and germ cells, and in female reproductive tissues including the ovaries, placenta and endometrium. However, the molecular role of VitD signalling and metabolism in reproductive function have not been fully established. Consequently, the aim of this work is to review current metabolic and molecular aspects of the VitD-VDR axis in reproductive medicine and to propose the direction of future research. Specifically, the influence of VitD on sperm motility, calcium handling, capacitation, acrosin reaction and lipid metabolism is examined. In addition, we will also discuss the effect of VitD on sex hormone secretion and receptor expression in primary granulosa cells, along with the impact on cytokine production in trophoblast cells. The review concludes with a discussion of the recent developments in VitD-VDR signalling specifically related to altered cellular bioenergetics, which is an emerging concept in the field of reproductive medicine.

    Related items

    Showing items related by title, author, creator and subject.

    • ‘Lnc’-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling
      Ong, M.; Cai, W.; Yuan, Y.; Leong, H.; Tan, T.; Mohammad, A.; You, M.; Arfuso, Frank; Goh, B.; Warrier, Sudha; Sethi, G.; Tolwinski, N.; Lobie, P.; Yap, C.; Hooi, S.; Huang, R.; Kumar, Alan Prem (2017)
      © 2017 The British Pharmacological Society Recent discoveries in the non-coding genome have challenged the original central dogma of molecular biology, as non-coding RNAs and related processes have been found to be important ...
    • Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test
      Clark, J.; Alves, S.; Gundlah, C.; Rocha, B.; Birzin, E.; Cai, S.; Flick, R.; Hayes, E.; Ho, K.; Warrier, Sudha; Pai, L.; Yudkovitz, J.; Fleischer, R.; Colwell, L.; Li, S.; Wilkinson, H.; Schaeffer, J.; Wilkening, R.; Mattingly, E.; Hammond, M.; Rohrer, S. (2012)
      Estrogen acts through two molecularly distinct receptors termed estrogen receptor alpha (ERa) and estrogen receptor beta (ERß) which bind estradiol with similar affinities and mediate the effects of estrogen throughout ...
    • Genome Expansion and Gene Loss in Powdery Mildew Fungi Reveal Tradeoffs in Extreme Parasitism
      Spanu, P.; Abbott, J.; Amselem, J.; Burgis, T.; Soanes, D.; Stüber, K.; Ver Loren van Themaat, E.; Brown, J.; Butcher, S.; Gurr, S.; Lebrun, M.; Ridout, C.; Schulze-Lefert, P.; Talbot, N.; Ahmadinejad, N.; Ametz, C.; Barton, G.; Benjdia, M.; Bidzinski, P.; Bindschedler, L.; Both, M.; Brewer, M.; Cadle-Davidson, L.; Cadle-Davidson, M.; Collemare, J.; Cramer, R.; Frenkel, O.; Godfrey, D.; Harriman, J.; Hoede, C.; King, B.; Klages, S.; Kleemann, J.; Knoll, D.; Koti, P.; Kreplak, J.; Lopez-Ruiz, Fran; Lu, X.; Maekawa, T.; Mahanil, S.; Micali, C.; Milgroom, M.; Montana, G.; Noir, S.; O’Connell, R.; Oberhaensli, S.; Parlange, F.; Pedersen, C.; Quesneville, H.; Reinhardt, R.; Rott, M.; Sacristán, S.; Schmidt, S.; Schön, M.; Skamnioti, P.; Sommer, H.; Stephens, A.; Takahara, H.; Thordal-Christensen, H.; Vigouroux, M.; Weßling, R.; Wicker, T.; Panstruga, R. (2010)
      Powdery mildews are phytopathogens whose growth and reproduction are entirely dependent on living plant cells. The molecular basis of this life-style, obligate biotrophy, remains unknown. We present the genome analysis ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin University would like to pay our respect to the indigenous members of our community by acknowledging the traditional owners of the land on which the Perth Campus is located, the Wadjuk people of the Nyungar Nation; and on our Kalgoorlie Campus, the Wongutha people of the North-Eastern Goldfields.
    Watch our traditional Aboriginal welcome