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    Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans

    Access Status
    Fulltext not available
    Authors
    Drummond, E.
    Flynn, S.
    Whelan, H.
    Nongonierma, A.
    Holton, T.
    Robinson, A.
    Egan, T.
    Cagney, G.
    Shields, D.
    Gibney, E.
    Newsholme, Philip
    Gaudel, C.
    Jacquier, J.
    Noronha, N.
    Fitzgerald, R.
    Brennan, L.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Drummond, E. and Flynn, S. and Whelan, H. and Nongonierma, A. and Holton, T. and Robinson, A. and Egan, T. et al. 2018. Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans. Journal of Agriculture and Food Chemistry. 66 (17): pp. 4352-4363.
    Source Title
    Journal of Agriculture and Food Chemistry
    DOI
    10.1021/acs.jafc.7b05550
    ISSN
    0021-8561
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/68833
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 American Chemical Society. Evidence exists to support the role of dairy derived proteins whey and casein in glycemic management. The objective of the present study was to use a cell screening method to identify a suitable casein hydrolysate and to examine its ability to impact glycemia related parameters in an animal model and in humans. Following screening for the ability to stimulate insulin secretion in pancreatic beta cells, a casein hydrolysate was selected and further studied in the ob/ob mouse model. An acute postprandial study was performed in 62 overweight and obese adults. Acute and long-term supplementation with the casein hydrolysate in in vivo studies in mice revealed a glucose lowering effect and a lipid reducing effect of the hydrolysate (43% reduction in overall liver fat). The postprandial human study revealed a significant increase in insulin secretion (p = 0.04) concomitant with a reduction in glucose (p = 0.03). The area under the curve for the change in glucose decreased from 181.84 ± 14.6 to 153.87 ± 13.02 (p = 0.009). Overall, the data supports further work on the hydrolysate to develop into a functional food product.

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