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    Preschool multiple-breath washout testing an official American Thoracic Society technical statement

    Access Status
    Fulltext not available
    Authors
    Robinson, P.
    Latzin, P.
    Ramsey, K.
    Stanojevic, S.
    Aurora, P.
    Davis, S.
    Gappa, M.
    Hall, Graham
    Horsley, A.
    Jensen, R.
    Lum, S.
    Milla, C.
    Nielsen, K.
    Pittman, J.
    Rosenfeld, M.
    Singer, F.
    Subbarao, P.
    Gustafsson, P.
    Ratjen, F.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Robinson, P. and Latzin, P. and Ramsey, K. and Stanojevic, S. and Aurora, P. and Davis, S. and Gappa, M. et al. 2018. Preschool multiple-breath washout testing an official American Thoracic Society technical statement. American Journal of Respiratory and Critical Care Medicine. 197 (5): pp. e1-e19.
    Source Title
    American Journal of Respiratory and Critical Care Medicine
    DOI
    10.1164/rccm.201801-0074ST
    ISSN
    1073-449X
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/68896
    Collection
    • Curtin Research Publications
    Abstract

    Copyright © 2018 by the American Thoracic Society Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial tree, although the extent to which this occurs can vary among conditions. The multiple-breath washout (MBW) test offers important insights into pediatric lung disease, not available through spirometry or resistance measurements. The European Respiratory Society/American Thoracic Society inert gas washout consensus statement led to the emergence of validated commercial equipment for the age group 6 years and above; specific recommendations for preschool children were beyond the scope of the document. Subsequently, the focus has shifted to MBW applications within preschool subjects (aged 2–6 yr), where a “window of opportunity” exists for early diagnosis of obstructive lung disease and intervention. Methods: This preschool-specific technical standards document was developed by an international group of experts, with expertise in both custom-built and commercial MBW equipment. A comprehensive review of published evidence was performed. Results: Recommendations were devised across areas that place specific age-related demands on MBW systems. Citing evidence where available in the literature, recommendations are made regarding procedures that should be used to achieve robust MBW results in the preschool age range. The present work also highlights the important unanswered questions that need to be addressed in future work. Conclusions: Consensus recommendations are outlined to direct interested groups of manufacturers, researchers, and clinicians in preschool device design, test performance, and data analysis for the MBW technique.

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