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    Patient-specific 3D printed pulmonary artery model with simulation of peripheral pulmonary embolism for developing optimal computed tomography pulmonary angiography protocols

    272246.pdf (1.952Mb)
    Access Status
    Open access via publisher
    Authors
    Aldosari, S.
    Jansen, S.
    Sun, Zhonghua
    Date
    2019
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Aldosari, S. and Jansen, S. and Sun, Z. 2019. Patient-specific 3D printed pulmonary artery model with simulation of peripheral pulmonary embolism for developing optimal computed tomography pulmonary angiography protocols. Quantitative Imaging in Medicine and Surgery. 9 (1): pp. 75-85.
    Source Title
    Quantitative Imaging in Medicine and Surgery
    DOI
    10.21037/qims.2018.10.13
    Additional URLs
    http://qims.amegroups.com/article/view/22424/21683
    ISSN
    2223-4292
    School
    School of Molecular and Life Sciences (MLS)
    URI
    http://hdl.handle.net/20.500.11937/70802
    Collection
    • Curtin Research Publications
    Abstract

    Background: Computed tomography pulmonary angiography (CTPA) is the preferred imaging modality for diagnosis of patients with suspected pulmonary embolism (PE). Radiation dose associated with CTPA has been significantly reduced due to the use of dose-reduction strategies, however, investigation of low-dose CTPA with use of different kVp and pitch values has not been systematically studied. The aim of this study was to utilize a 3D printed pulmonary model with simulation of small thrombus in the pulmonary arteries for development of optimal CTPA protocols. Methods: Animal blood clots were inserted into the pulmonary arteries to simulate peripheral embolism based on a realistic 3D printed pulmonary artery model. The 3D printed model was scanned with 192-slice 3rd generation dual-source CT with 1 mm slice thickness and 0.5 mm reconstruction interval. All images were reconstructed with advanced modelled iterative reconstruction (IR) at a strength level of 3. CTPA scanning parameters were as follows: 70, 80, 100 and 120 kVp, 0.9, 2.2 and 3.2 pitch values. Quantitative assessment of image quality was determined by measuring signal-to-noise ratio (SNR) in both main pulmonary arteries, while qualitative analysis of images was scored by two experienced radiologists (score of 1 indicates poor visualization of thrombus with no confidence, and score of 5 excellent visualization of thrombus with high confidence) to determine the image quality in relation to different scanning protocols for detection of thrombus in the pulmonary arteries. Results: No significant differences were found in SNR measurements among all CTPA protocols (P>0.05), regardless of kVp or pitch values used, although SNR was higher with 120 kVp and 0.9 and 2.2 pitch protocols than that in other protocols. The thrombi were detected in all images, with 70 kVp and 3.2 pitch protocol scored the lowest with a score of 3 by two observers, and images with other protocols were scored 4 or 5. Lowering kVp from 120 to 70 with use of high-pitch 2.2 or 3.2 protocol resulted in up to 80% dose reduction without significantly affecting image quality. Conclusions: Low-dose CT pulmonary angiography protocols comprising 70 kVp and high pitch 2.2 or 3.2 allow for detection of peripheral PE with significant reduction in radiation dose while images are still considered diagnostic.

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    • Optimization of computed tomography pulmonary angiography protocols using 3D printed model with simulation of pulmonary embolism
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      Background: Three-dimensional (3D) printing has been shown to accurately replicate anatomical structures and pathologies in complex cardiovascular disease. Application of 3D printed models to simulate pulmonary arteries ...
    • Patient-specific three-dimensional printed pulmonary artery model: A preliminary study
      Aldosari, S.; Squelch, A.; Sun, Zhonghua (2018)
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    • Double low-dose computed tomography pulmonary angiography in the diagnosis of pulmonary embolism
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      The purpose of this study is to investigate the feasibility of double low-dose (low radiation and low contrast medium doses) computed tomography pulmonary angiography (CTPA) in the diagnosis of pulmonary embolism. This ...
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