Hypermutation In Pancreatic Cancer

Humphris, J.; Patch, A.; Nones, K.; Bailey, P.; Johns, A.; Mckay, S.; Chang, D.; Miller, D.; Pajic, M.; Kassahn, K.; Quinn, M.; Bruxner, T.; Christ, A.; Harliwong, I.; Idrisoglu, S.; Manning, S.; Nourse, C.; Nourbakhsh, E.; Stone, A.; Wilson, P.; Anderson, M.; Fink, J.; Holmes, O.; Kazakoff, S.; Leonard, C.; Newell, F.; Waddell, N.; Wood, S.; Mead, R.; Xu, Q.; Wu, J.; Pinese, M.; Cowley, M.; Jones, M.; Nagrial, A.; Chin, V.; Chantrill, L.; Mawson, A.; Chou, A.; Scarlett, C.; Pinho, A.; Rooman, I.; Giry-Laterriere, M.; Samra, J.; Kench, J.; Merrett, N.; Toon, C.; Epari, K.; Nguyen, N.; Barbour, A.; Zeps, Nikolajs; Jamieson, N.; McKay, C.; Carter, C.; Dickson, E.; Graham, J.; Duthie, F.; Oien, K.; Hair, J.; Morton, J.; Sansom, O.; Gruetzmann, R.; Hruban, R.; Maitra, A.; Iacobuzio-Donahue, C.; Schulick, R.; Wolfgang, C.; Morgan, R.; Lawlor, R.; Rusev, B.; Corbo, V.; Salvia, R.; Cataldo, I.; Tortora, G.; Tempero, M.; Hofmann, O.; Eshleman, J.; Pilarsky, C.; Scarpa, A.; Musgrove, E.; Gill, A.; Pearson, J.; Grimmond, S.; Waddell, N.; Biankin, A.

doi:10.1053/j.gastro.2016.09.060

dc.contributor.author	Humphris, J.
dc.contributor.author	Patch, A.
dc.contributor.author	Nones, K.
dc.contributor.author	Bailey, P.
dc.contributor.author	Johns, A.
dc.contributor.author	Mckay, S.
dc.contributor.author	Chang, D.
dc.contributor.author	Miller, D.
dc.contributor.author	Pajic, M.
dc.contributor.author	Kassahn, K.
dc.contributor.author	Quinn, M.
dc.contributor.author	Bruxner, T.
dc.contributor.author	Christ, A.
dc.contributor.author	Harliwong, I.
dc.contributor.author	Idrisoglu, S.
dc.contributor.author	Manning, S.
dc.contributor.author	Nourse, C.
dc.contributor.author	Nourbakhsh, E.
dc.contributor.author	Stone, A.
dc.contributor.author	Wilson, P.
dc.contributor.author	Anderson, M.
dc.contributor.author	Fink, J.
dc.contributor.author	Holmes, O.
dc.contributor.author	Kazakoff, S.
dc.contributor.author	Leonard, C.
dc.contributor.author	Newell, F.
dc.contributor.author	Waddell, N.
dc.contributor.author	Wood, S.
dc.contributor.author	Mead, R.
dc.contributor.author	Xu, Q.
dc.contributor.author	Wu, J.
dc.contributor.author	Pinese, M.
dc.contributor.author	Cowley, M.
dc.contributor.author	Jones, M.
dc.contributor.author	Nagrial, A.
dc.contributor.author	Chin, V.
dc.contributor.author	Chantrill, L.
dc.contributor.author	Mawson, A.
dc.contributor.author	Chou, A.
dc.contributor.author	Scarlett, C.
dc.contributor.author	Pinho, A.
dc.contributor.author	Rooman, I.
dc.contributor.author	Giry-Laterriere, M.
dc.contributor.author	Samra, J.
dc.contributor.author	Kench, J.
dc.contributor.author	Merrett, N.
dc.contributor.author	Toon, C.
dc.contributor.author	Epari, K.
dc.contributor.author	Nguyen, N.
dc.contributor.author	Barbour, A.
dc.contributor.author	Zeps, Nikolajs
dc.contributor.author	Jamieson, N.
dc.contributor.author	McKay, C.
dc.contributor.author	Carter, C.
dc.contributor.author	Dickson, E.
dc.contributor.author	Graham, J.
dc.contributor.author	Duthie, F.
dc.contributor.author	Oien, K.
dc.contributor.author	Hair, J.
dc.contributor.author	Morton, J.
dc.contributor.author	Sansom, O.
dc.contributor.author	Gruetzmann, R.
dc.contributor.author	Hruban, R.
dc.contributor.author	Maitra, A.
dc.contributor.author	Iacobuzio-Donahue, C.
dc.contributor.author	Schulick, R.
dc.contributor.author	Wolfgang, C.
dc.contributor.author	Morgan, R.
dc.contributor.author	Lawlor, R.
dc.contributor.author	Rusev, B.
dc.contributor.author	Corbo, V.
dc.contributor.author	Salvia, R.
dc.contributor.author	Cataldo, I.
dc.contributor.author	Tortora, G.
dc.contributor.author	Tempero, M.
dc.contributor.author	Hofmann, O.
dc.contributor.author	Eshleman, J.
dc.contributor.author	Pilarsky, C.
dc.contributor.author	Scarpa, A.
dc.contributor.author	Musgrove, E.
dc.contributor.author	Gill, A.
dc.contributor.author	Pearson, J.
dc.contributor.author	Grimmond, S.
dc.contributor.author	Waddell, N.
dc.contributor.author	Biankin, A.
dc.date.accessioned	2018-12-13T09:07:58Z
dc.date.available	2018-12-13T09:07:58Z
dc.date.created	2018-12-12T02:47:03Z
dc.date.issued	2017
dc.identifier.citation	Humphris, J. and Patch, A. and Nones, K. and Bailey, P. and Johns, A. and Mckay, S. and Chang, D. et al. 2017. Hypermutation In Pancreatic Cancer. Gastroenterology. 152 (1): pp. 68-74.e2.
dc.identifier.uri	http://hdl.handle.net/20.500.11937/70852
dc.identifier.doi	10.1053/j.gastro.2016.09.060
dc.description.abstract	© 2017 AGA Institute Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation burden and defective DNA repair are associated with response to immune checkpoint inhibitors in several other cancer types. We interrogated 385 pancreatic cancer genomes to define hypermutation and its causes. Mutational signatures inferring defects in DNA repair were enriched in those with the highest mutation burdens. Mismatch repair deficiency was identified in 1% of tumors harboring different mechanisms of somatic inactivation of MLH1 and MSH2. Defining mutation load in individual pancreatic cancers and the optimal assay for patient selection may inform clinical trial design for immunotherapy in pancreatic cancer.
dc.publisher	W.B. Saunders Co.
dc.title	Hypermutation In Pancreatic Cancer
dc.type	Journal Article
dcterms.source.volume	152
dcterms.source.number	1
dcterms.source.startPage	68
dcterms.source.endPage	74.e2
dcterms.source.issn	0016-5085
dcterms.source.title	Gastroenterology
curtin.accessStatus	Fulltext not available

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