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    Highly exposed Pt nanoparticles supported on porous graphene for electrochemical detection of hydrogen peroxide in living cells

    Access Status
    Fulltext not available
    Authors
    Liu, Jian
    Bo, X.
    Zhao, Z.
    Guo, L.
    Date
    2015
    Type
    Journal Article
    
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    Citation
    Liu, J. and Bo, X. and Zhao, Z. and Guo, L. 2015. Highly exposed Pt nanoparticles supported on porous graphene for electrochemical detection of hydrogen peroxide in living cells. Biosensors and Bioelectronics. 74: pp. 71-77.
    Source Title
    Biosensors and Bioelectronics
    DOI
    10.1016/j.bios.2015.06.042
    ISSN
    0956-5663
    School
    WASM: Minerals, Energy and Chemical Engineering (WASM-MECE)
    URI
    http://hdl.handle.net/20.500.11937/70874
    Collection
    • Curtin Research Publications
    Abstract

    © 2015 Elsevier B.V. In this study, we developed a novel biosensor based on highly exposed Pt nanoparticles (Pt NPs) decorated porous graphene (PG) for the reliable detection of extracellular hydrogen peroxide (H<inf>2</inf>O<inf>2</inf>) released from living cells. The commercially available low-cost hydrophilic CaCO<inf>3</inf> spheres were used as template for preparing PG. The porous structure provided larger surface area and more active sites. Due to the porous structure of PG, the Pt NPs supported on PG were not secluded by aggregated graphene layers and were highly exposed to target molecules. Ultrafine Pt NPs were well dispersed and loaded on PG by a method of microwave assistance. Electrochemical performances of the Pt/PG nanocomposites modified glassy carbon electrode (GCE) were investigated. The electrocatalytic reduction of H<inf>2</inf>O<inf>2</inf> showed a wide linear range from 1 to 1477µM, with a high sensitivity of 341.14µAmM<sup>-1</sup>cm<sup>-2</sup> and a limit of detection (LOD) as low as 0.50µM. Moreover, the Pt/PG/GCE exhibited excellent anti-interference property, reproducibility and long-term storage stability. Because of these remarkable analytical advantages, the constructed sensor was used to determine H<inf>2</inf>O<inf>2</inf> released from living cells with satisfactory results. The superior catalytic activity makes Pt/PG nanocomposites a promising candidate for electrochemical sensors and biosensors design.

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