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    Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis

    Access Status
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    Authors
    Macdonald, S.
    Bosio, E.
    Neil, C.
    Arendts, Glenn
    Burrows, S.
    Smart, L.
    Brown, S.
    Fatovich, Daniel
    Date
    2017
    Type
    Journal Article
    
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    Citation
    Macdonald, S. and Bosio, E. and Neil, C. and Arendts, G. and Burrows, S. and Smart, L. and Brown, S. et al. 2017. Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis. INFLAMMATION RESEARCH. 66 (7): pp. 611-619.
    Source Title
    INFLAMMATION RESEARCH
    DOI
    10.1007/s00011-017-1043-5
    ISSN
    1023-3830
    School
    School of Nursing, Midwifery and Paramedicine
    URI
    http://hdl.handle.net/20.500.11937/71385
    Collection
    • Curtin Research Publications
    Abstract

    © 2017, Springer International Publishing. Objective and design: Resistin and neutrophil gelatinase-associated lipocalin (NGAL) are upregulated in circulating leucocytes in sepsis, but the significance of this is uncertain. We evaluated associations between Resistin and NGAL with endothelial cell activation and clinical outcomes in a prospective observational study in the Emergency Department (ED). Methods: Serum levels of Resistin, NGAL, inflammatory cytokines (IL-6, IL-10) and soluble endothelial adhesion molecules (VCAM-1, ICAM-1) were measured at defined time points up to 24 h. Patterns and relationships between markers were investigated using linear mixed regression models. Predictive values for clinical outcomes for markers at enrollment were assessed by logistic regression and receiver operator characteristic (ROC) curves. Results: 186 participants (89 septic-shock, 69 sepsis, 28 uncomplicated infection) were compared with 29 healthy controls. Median Resistin and NGAL were higher in uncomplicated infection compared to controls, and in septic shock compared to non-shock sepsis. Resistin and NGAL correlated with IL-6 and IL-10, with VCAM-1 and ICAM-1, and with organ failure. Resistin and NGAL were associated with septic shock but had limited predictive utility for mortality. Conclusion: Resistin and NGAL correlate with expression of endothelial cell adhesion molecules in sepsis. Further evaluation of the role of Resistin and NGAL in sepsis pathogenesis is warranted.

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