Show simple item record

dc.contributor.authorMacdonald, S.
dc.contributor.authorBosio, E.
dc.contributor.authorNeil, C.
dc.contributor.authorArendts, Glenn
dc.contributor.authorBurrows, S.
dc.contributor.authorSmart, L.
dc.contributor.authorBrown, S.
dc.contributor.authorFatovich, Daniel
dc.identifier.citationMacdonald, S. and Bosio, E. and Neil, C. and Arendts, G. and Burrows, S. and Smart, L. and Brown, S. et al. 2017. Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis. INFLAMMATION RESEARCH. 66 (7): pp. 611-619.

© 2017, Springer International Publishing. Objective and design: Resistin and neutrophil gelatinase-associated lipocalin (NGAL) are upregulated in circulating leucocytes in sepsis, but the significance of this is uncertain. We evaluated associations between Resistin and NGAL with endothelial cell activation and clinical outcomes in a prospective observational study in the Emergency Department (ED). Methods: Serum levels of Resistin, NGAL, inflammatory cytokines (IL-6, IL-10) and soluble endothelial adhesion molecules (VCAM-1, ICAM-1) were measured at defined time points up to 24 h. Patterns and relationships between markers were investigated using linear mixed regression models. Predictive values for clinical outcomes for markers at enrollment were assessed by logistic regression and receiver operator characteristic (ROC) curves. Results: 186 participants (89 septic-shock, 69 sepsis, 28 uncomplicated infection) were compared with 29 healthy controls. Median Resistin and NGAL were higher in uncomplicated infection compared to controls, and in septic shock compared to non-shock sepsis. Resistin and NGAL correlated with IL-6 and IL-10, with VCAM-1 and ICAM-1, and with organ failure. Resistin and NGAL were associated with septic shock but had limited predictive utility for mortality. Conclusion: Resistin and NGAL correlate with expression of endothelial cell adhesion molecules in sepsis. Further evaluation of the role of Resistin and NGAL in sepsis pathogenesis is warranted.

dc.titleResistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis
dc.typeJournal Article
dcterms.source.titleINFLAMMATION RESEARCH
curtin.departmentSchool of Nursing, Midwifery and Paramedicine
curtin.accessStatusFulltext not available

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record