14-3-3 zeta deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders
dc.contributor.author | Xu, X. | |
dc.contributor.author | Jaehne, E. | |
dc.contributor.author | Greenberg, Z. | |
dc.contributor.author | McCarthy, P. | |
dc.contributor.author | Saleh, E. | |
dc.contributor.author | Parish, C. | |
dc.contributor.author | Camera, D. | |
dc.contributor.author | Heng, Julian | |
dc.contributor.author | Haas, M. | |
dc.contributor.author | Baune, B. | |
dc.contributor.author | Ratnayake, U. | |
dc.contributor.author | Van Den Buuse, M. | |
dc.contributor.author | Lopez, A. | |
dc.contributor.author | Ramshaw, H. | |
dc.contributor.author | Schwarz, Q. | |
dc.date.accessioned | 2018-12-13T09:10:22Z | |
dc.date.available | 2018-12-13T09:10:22Z | |
dc.date.created | 2018-12-12T02:47:06Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Xu, X. and Jaehne, E. and Greenberg, Z. and McCarthy, P. and Saleh, E. and Parish, C. and Camera, D. et al. 2015. 14-3-3 zeta deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders. Scientific Reports. 5: 12434. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/71523 | |
dc.identifier.doi | 10.1038/srep12434 | |
dc.description.abstract |
© 2015 Macmillan Publishers Limited. Sequencing and expression analyses implicate 14-3-3? as a genetic risk factor for neurodevelopmental disorders such as schizophrenia and autism. In support of this notion, we recently found that 14-3-3?<sup>-/-</sup> mice in the Sv/129 background display schizophrenia-like defects. As epistatic interactions play a significant role in disease pathogenesis we generated a new congenic strain in the BALB/c background to determine the impact of genetic interactions on the 14-3-3?<sup>-/-</sup> phenotype. In addition to replicating defects such as aberrant mossy fibre connectivity and impaired spatial memory, our analysis of 14-3-3?<sup>-/-</sup> BALB/c mice identified enlarged lateral ventricles, reduced synaptic density and ectopically positioned pyramidal neurons in all subfields of the hippocampus. In contrast to our previous analyses, 14-3-3?<sup>-/-</sup> BALB/c mice lacked locomotor hyperactivity that was underscored by normal levels of the dopamine transporter (DAT) and dopamine signalling. Taken together, our results demonstrate that dysfunction of 14-3-3? gives rise to many of the pathological hallmarks associated with the human condition. 14-3-3? -deficient BALB/c mice therefore provide a novel model to address the underlying biology of structural defects affecting the hippocampus and ventricle, and cognitive defects such as hippocampal-dependent learning and memory. | |
dc.publisher | Nature Publishing Group | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | 14-3-3 zeta deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders | |
dc.type | Journal Article | |
dcterms.source.volume | 5 | |
dcterms.source.issn | 2045-2322 | |
dcterms.source.title | Scientific Reports | |
curtin.department | Health Sciences Research and Graduate Studies | |
curtin.accessStatus | Open access via publisher |
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