Glutamine and the immune system
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Cruzat, V. and Newsholme, P. 2017. Glutamine and the immune system. In Nutrition, Immunity, and Infection, 357-374.
Nutrition, Immunity, and Infection
School of Pharmacy and Biomedical Sciences
© 2018 by Taylor & Francis Group, LLC. Glutamine is recognized as a crucial and versatile amino acid for cell survival and growth, playing an important role in metabolism. Moreover, compared to all other amino acids in the body, glutamine is present at the highest extracellular concentration, and is considered the most abundant free amino acid. In fact, in addition to glucose, glutamine represents a primary nutrient for maintenance of the body’s homeostasis (Newsholme et al. 2003a).
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Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exerciseCruzat, Vinicius; Rogero, M.; Tirapegui, J. (2010)In this study, we investigated the effect of the supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine on plasma levels markers of muscle damage and levels of ...
L-glutamine and L-alanine supplementation increase glutamine-glutathione axis and muscle HSP-27 in rats trained using a progressive high-intensity resistance exerciseLeite, J.; Raizel, R.; Hypólito, T.; Dos Santos Rosa, T.; Cruzat, Vinicius; Tirapegui, J. (2016)In this study we investigated the chronic effects of oral L-glutamine and L-alanine supplementation, either in their free or dipeptide form, on glutamine-glutathione (GLN-GSH) axis and cytoprotection mediated by HSP-27 ...
Cruzat, Vinicius; Rogero, M.; Keane, Kevin; Curi, R.; Newsholme, Philip (2018)© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Glutamine is the most abundant and versatile amino acid in the body. In health and disease, the rate of glutamine consumption by immune cells is similar or greater ...