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    Deciphering the roles of lncRNAs in breast development and disease

    Access Status
    Fulltext not available
    Authors
    Richard, J.
    Eichhorn, Pieter
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Richard, J. and Eichhorn, P. 2018. Deciphering the roles of lncRNAs in breast development and disease. Oncotarget. 9 (28): pp. 20179-20212.
    Source Title
    Oncotarget
    DOI
    10.18632/oncotarget.24591
    ISSN
    1949-2553
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/72378
    Collection
    • Curtin Research Publications
    Abstract

    © Charles Richard et al. Breast cancer is the second leading cause of cancer related deaths in women. It is therefore important to understand the mechanisms underlying breast cancer development as well as raises the need for enhanced, non-invasive strategies for novel prognostic and diagnostic methods. The emergence of long non-coding RNAs (lncRNAs) as potential key players in neoplastic disease has received considerable attention over the past few years. This relatively new class of molecular regulators has been shown from ongoing research to act as critical players for key biological processes. Deregulated expression levels of lncRNAs have been observed in a number of cancers including breast cancer. Furthermore, lncRNAs have been linked to breast cancer initiation, progression, metastases and to limit sensitivity to certain targeted therapeutics. In this review we provide an update on the lncRNAs associated with breast cancer and mammary gland development and illustrate the versatility of such lncRNAs in gene control, differentiation and development both in normal physiological conditions and in diseased states. We also highlight the therapeutic and diagnostic potential of lncRNAs in cancer.

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