Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    The expanding roles of long non-coding RNAs in the regulation of cancer stem cells

    Access Status
    Fulltext not available
    Authors
    Ma, Z.
    Wang, Y.
    Xin, H.
    Wang, L.
    Arfuso, Frank
    Dharmarajan, A.
    Kumar, A.
    Wang, H.
    Tang, F.
    Warrier, Sudha
    Tergaonkar, V.
    Sethi, G.
    Date
    2019
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Ma, Z. and Wang, Y. and Xin, H. and Wang, L. and Arfuso, F. and Dharmarajan, A. and Kumar, A. et al. 2019. The expanding roles of long non-coding RNAs in the regulation of cancer stem cells. International Journal of Biochemistry and Cell Biology. 108: pp. 17-20.
    Source Title
    International Journal of Biochemistry and Cell Biology
    DOI
    10.1016/j.biocel.2019.01.003
    ISSN
    1357-2725
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/73758
    Collection
    • Curtin Research Publications
    Abstract

    Long non-coding RNAs (lncRNAs) are a novel class of gene regulators playing multifaceted roles in physiological processes as well as pathological conditions such as cancer. Cancer stem cells (CSCs) are a small subset of tumor cells that constitute the origin and development of various malignant tumors. CSCs have been identified in a wide spectrum of human tumors and could act as a critical link underlying the processes of tumor metastasis and recurrence. Mounting evidence indicates that lncRNAs are aberrantly expressed in diverse CSCs and regulate CSC properties at different molecular levels. Here, we very briefly summarize the recent findings on the potential roles of lncRNAs in regulating various functions of CSCs, and elaborate on how can lncRNAs impact CSC properties via interacting with other macromolecules at the epigenetic, transcriptional, and post-transcriptional levels. This mini-review also highlights the understanding of the modular regulatory principles of lncRNA interactions in CSCs.

    Related items

    Showing items related by title, author, creator and subject.

    • Platforms for Investigating LncRNA Functions
      Charles Richard, J.; Eichhorn, Pieter (2018)
      © 2018, Society for Laboratory Automation and Screening. Prior to the sequencing of the human genome, it was presumed that most of the DNA coded for proteins. However, with the advent of next-generation sequencing, it has ...
    • ‘Lnc’-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling
      Ong, M.; Cai, W.; Yuan, Y.; Leong, H.; Tan, T.; Mohammad, A.; You, M.; Arfuso, Frank; Goh, B.; Warrier, Sudha; Sethi, G.; Tolwinski, N.; Lobie, P.; Yap, C.; Hooi, S.; Huang, R.; Kumar, Alan Prem (2017)
      © 2017 The British Pharmacological Society Recent discoveries in the non-coding genome have challenged the original central dogma of molecular biology, as non-coding RNAs and related processes have been found to be important ...
    • Deciphering the roles of lncRNAs in breast development and disease
      Richard, J.; Eichhorn, Pieter (2018)
      © Charles Richard et al. Breast cancer is the second leading cause of cancer related deaths in women. It is therefore important to understand the mechanisms underlying breast cancer development as well as raises the need ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.