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    Insights into the Biology and Therapeutic Applications of Neural Stem Cells

    Access Status
    Open access via publisher
    Authors
    Harris, L.
    Zalucki, O.
    Piper, M.
    Heng, Julian
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Harris, L. and Zalucki, O. and Piper, M. and Heng, J. 2016. Insights into the Biology and Therapeutic Applications of Neural Stem Cells. Stem Cells International. 2016: 9745315.
    Source Title
    Stem Cells International
    DOI
    10.1155/2016/9745315
    ISSN
    1687-9678
    School
    Health Sciences Research and Graduate Studies
    URI
    http://hdl.handle.net/20.500.11937/72682
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 Lachlan Harris et al. The cerebral cortex is essential for our higher cognitive functions and emotional reasoning. Arguably, this brain structure is the distinguishing feature of our species, and yet our remarkable cognitive capacity has seemingly come at a cost to the regenerative capacity of the human brain. Indeed, the capacity for regeneration and neurogenesis of the brains of vertebrates has declined over the course of evolution, from fish to rodents to primates. Nevertheless, recent evidence supporting the existence of neural stem cells (NSCs) in the adult human brain raises new questions about the biological significance of adult neurogenesis in relation to ageing and the possibility that such endogenous sources of NSCs might provide therapeutic options for the treatment of brain injury and disease. Here, we highlight recent insights and perspectives on NSCs within both the developing and adult cerebral cortex. Our review of NSCs during development focuses upon the diversity and therapeutic potential of these cells for use in cellular transplantation and in the modeling of neurodevelopmental disorders. Finally, we describe the cellular and molecular characteristics of NSCs within the adult brain and strategies to harness the therapeutic potential of these cell populations in the treatment of brain injury and disease.

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